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Title: NME proteins regulate class switch recombination
Authors: Zheng, Simin
Kusnadi, Anthony
Choi, Jee Eun
Vuong, Bao Q.
Rhodes, Daniela
Chaudhuri, Jayanta
Keywords: DNA Recombination
Science::Biological sciences
Issue Date: 2018
Source: Zheng, S., Kusnadi, A., Choi, J. E., Vuong, B. Q., Rhodes, D., & Chaudhuri, J. (2018). NME proteins regulate class switch recombination. FEBS Letters, 593(1), 80-87. doi:10.1002/1873-3468.13290
Series/Report no.: FEBS Letters
Abstract: Class switch recombination (CSR) in B cells involves deletion‐recombination at switch (S) region DNA and is important for the diversification of antibody isotypes during an immune response. Here, we identify two NME [NM23/NDPK (nucleoside diphosphate kinase)] isoforms, NME1 and NME2, as novel players in this process. Knockdown of NME2 leads to decreased CSR, while knockdown of the highly homologous NME1 results in increased CSR. Interestingly, these NME proteins also display differential occupancy at S regions during CSR despite their homology; NME1 binds to S regions prior to stimulation, while NME2 binds to S regions only after stimulation. To the best of our knowledge, this represents the first report of a role for these proteins in the regulation of CSR.
ISSN: 0014-5793
Rights: © 2018 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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