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|Title:||NME proteins regulate class switch recombination||Authors:||Zheng, Simin
Choi, Jee Eun
Vuong, Bao Q.
|Issue Date:||2018||Source:||Zheng, S., Kusnadi, A., Choi, J. E., Vuong, B. Q., Rhodes, D., & Chaudhuri, J. (2018). NME proteins regulate class switch recombination. FEBS Letters, 593(1), 80-87. doi:10.1002/1873-3468.13290||Series/Report no.:||FEBS Letters||Abstract:||Class switch recombination (CSR) in B cells involves deletion‐recombination at switch (S) region DNA and is important for the diversification of antibody isotypes during an immune response. Here, we identify two NME [NM23/NDPK (nucleoside diphosphate kinase)] isoforms, NME1 and NME2, as novel players in this process. Knockdown of NME2 leads to decreased CSR, while knockdown of the highly homologous NME1 results in increased CSR. Interestingly, these NME proteins also display differential occupancy at S regions during CSR despite their homology; NME1 binds to S regions prior to stimulation, while NME2 binds to S regions only after stimulation. To the best of our knowledge, this represents the first report of a role for these proteins in the regulation of CSR.||URI:||https://hdl.handle.net/10356/86130
|ISSN:||0014-5793||DOI:||http://dx.doi.org/10.1002/1873-3468.13290||Rights:||© 2018 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SBS Journal Articles|
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