Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/90338
Title: Darkness in the human gene and protein function space : widely modest or absent illumination by the life science literature and the trend for fewer protein function discoveries since 2000
Authors: Sinha, Swati
Eisenhaber, Birgit
Jensen, Lars Juhl
Kalbuaji, Bharata
Eisenhaber, Frank
Keywords: Complete Human Genome
Gene Function Discovery
Engineering::Computer science and engineering
Issue Date: 2018
Source: Sinha, S., Eisenhaber, B., Jensen, L. J., Kalbuaji, B., & Eisenhaber, F. (2018). Darkness in the human gene and protein function space : widely modest or absent illumination by the life science literature and the trend for fewer protein function discoveries since 2000. Proteomics, 18(21-22), 1800093-. doi:10.1002/pmic.201800093
Series/Report no.: Proteomics
Abstract: The mentioning of gene names in the body of the scientific literature 1901–2017 and their fractional counting is used as a proxy to assess the level of biological function discovery. A literature score of one has been defined as full publication equivalent (FPE), the amount of literature necessary to achieve one publication solely dedicated to a gene. It has been found that less than 5000 human genes have each at least 100 FPEs in the available literature corpus. This group of elite genes (4817 protein‐coding genes, 119 non‐coding RNAs) attracts the overwhelming majority of the scientific literature about genes. Yet, thousands of proteins have never been mentioned at all, ≈2000 further proteins have not even one FPE of literature and, for ≈4600 additional proteins, the FPE count is below 10. The protein function discovery rate measured as numbers of proteins first mentioned or crossing a threshold of accumulated FPEs in a given year has grown until 2000 but is in decline thereafter. This drop is partially offset by function discoveries for non‐coding RNAs. The full human genome sequencing does not boost the function discovery rate. Since 2000, the fastest growing group in the literature is that with at least 500 FPEs per gene.
URI: https://hdl.handle.net/10356/90338
http://hdl.handle.net/10220/49910
ISSN: 1615-9853
DOI: 10.1002/pmic.201800093
Rights: © 2018 Bioinformatics Institute. Proteomics Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCSE Journal Articles

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