Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/104481
Title: Supramolecular self-assembly of poly(ethylene glycol)-b-poly(l-lysine) and EDTA into nanofibers and their synergistic inhibition of Escherichia coli proliferation
Authors: Pu, Yuji
Khin, Mya Mya
Chan-Park, Mary Bee Eng
Keywords: Engineering::Chemical engineering
Polymers
Biomaterials
Issue Date: 2018
Source: Pu, Y., Khin, M. M., & Chan-Park, M. B. (2018). Supramolecular self-assembly of poly(ethylene glycol)-b-poly(l-lysine) and EDTA into nanofibers and their synergistic inhibition of Escherichia coli proliferation. Materials Letters, 223, 69-72. doi:10.1016/j.matlet.2018.04.019
Series/Report no.: Materials Letters
Abstract: Supramolecular assembly of amphiphilic polymer poly(ethylene glycol)-b-poly(l-lysine) (PEG-b-PLL) and ethylenediaminetetraacetic acid (EDTA) were used to efficiently inhibit E. coli proliferation. PEG-b-PLL is a moderate antibacterial polymer itself with a minimum inhibitory concentration (MIC) of 43.8 μg/mL, and it inhibits bacteria by the electrostatic interactions and hydrophobic interactions with bacteria membrane. EDTA induces the lipopolysaccharide release and enhanced membrane permeability of E. coli, and affects the divalent ion equilibrium on the bacteria membrane. The self-assembly of PEG-b-PLL and EDTA into spindly nanofibers, showing synergistic inhibition of E. coli (MIC: 10.9 μg/mL). Our strategy provides a new way of designing supramolecular antibacterials with synergistic antibacterial effects by virtue of different inhibition mechanisms.
URI: https://hdl.handle.net/10356/104481
http://hdl.handle.net/10220/50018
ISSN: 0167-577X
DOI: 10.1016/j.matlet.2018.04.019
Rights: © 2018 Elsevier B.V. All rights reserved. This paper was published in Materials Letters and is made available with permission of Elsevier B.V.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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