Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction
Date of Issue2019
School of Chemical and Biomedical Engineering
Real-time imaging of kidney function is important to assess the nephrotoxicity of drugs and monitor the progression of renal diseases; however, it remains challenging because of the lack of optical agents with high renal clearance and high signal-tobackground ratio (SBR). Herein, a second near-infrared (NIR-II) fluorescent molecular semiconductor (CDIR2) is synthesized for realtime imaging of kidney dysfunction in living mice. CDIR2 not only has a high renal clearance efficiency (~90% injection dosage at 24 h postinjection), but also solely undergoes glomerular filtration into urine without being reabsorbed and secreted in renal tubules. Such a unidirectional renal clearance pathway of CDIR2 permits real-time monitoring of kidney dysfunction in living mice upon nephrotoxic exposure. Thus, this study not only introduces a molecular renal probe but also provides useful molecular guidelines to increase the renal clearance efficiency of NIR-II fluorescent agents.
Angewandte Chemie International Edition
This is the peer reviewed version of the following article: Huang, J., Xie, C., Zhang, X., Jiang, Y., Li, J., Fan, Q., & Pu, K. (2019). Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction. Angewandte Chemie International Edition, 58(42), 15120-15127, which has been published in final form at https://doi.org/10.1002/anie.201909560. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.