Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83301
Title: Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction
Authors: Li, Jingchao
Huang, Jiaguo
Fan, Quli
Xie, Chen
Zhang, Xiaodong
Jiang, Yuyan
Pu, Kanyi
Keywords: Real-time Imaging
Kidney Dysfunction
Engineering::Chemical engineering
Issue Date: 2019
Source: Huang, J., Xie, C., Zhang, X., Jiang, Y., Li, J., Fan, Q., & Pu, K. (2019). Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction. Angewandte Chemie International Edition, 58(42), 15120-15127. doi:10.1002/anie.201909560
Series/Report no.: Angewandte Chemie International Edition
Abstract: Real-time imaging of kidney function is important to assess the nephrotoxicity of drugs and monitor the progression of renal diseases; however, it remains challenging because of the lack of optical agents with high renal clearance and high signal-tobackground ratio (SBR). Herein, a second near-infrared (NIR-II) fluorescent molecular semiconductor (CDIR2) is synthesized for realtime imaging of kidney dysfunction in living mice. CDIR2 not only has a high renal clearance efficiency (~90% injection dosage at 24 h postinjection), but also solely undergoes glomerular filtration into urine without being reabsorbed and secreted in renal tubules. Such a unidirectional renal clearance pathway of CDIR2 permits real-time monitoring of kidney dysfunction in living mice upon nephrotoxic exposure. Thus, this study not only introduces a molecular renal probe but also provides useful molecular guidelines to increase the renal clearance efficiency of NIR-II fluorescent agents.
URI: https://hdl.handle.net/10356/83301
http://hdl.handle.net/10220/50094
ISSN: 1433-7851
DOI: 10.1002/anie.201909560
Rights: This is the peer reviewed version of the following article: Huang, J., Xie, C., Zhang, X., Jiang, Y., Li, J., Fan, Q., & Pu, K. (2019). Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction. Angewandte Chemie International Edition, 58(42), 15120-15127, which has been published in final form at https://doi.org/10.1002/anie.201909560. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: embargo_20201021
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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  Until 2020-10-21
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