A semiconducting polymer nano-prodrug for hypoxia-activated synergetic photodynamic cancer therapy
Date of Issue2019
School of Chemical and Biomedical Engineering
Photodynamic therapy (PDT) holds great promise for cancer therapy; however, its efficacy is often compromised by tumor hypoxia. Herein, we report the synthesis of a semiconducting polymer nanoprodrug (SPNpd) that not only efficiently generates singlet oxygen (1O2) under NIR photoirradiation but also specifically activates its chemotherapeutic action in hypoxic tumor microenvironment. SPNpd is selfassembled from a amphiphilic polymer brush, which comprises a light-responsive photodynamic backbone grafted with poly(ethylene glycol) and conjugated with a chemodrug through hypoxia-cleavable linkers. The well-defined and compact nanostructure of SPNpd (30 nm) enables accumulation in the tumor of living mice. Owing to these features, SPNpd exerts synergistic photodynamic and chemo-therapy, and effectively inhibits tumor growth in a xenograft tumor mouse model. This study represents the first hypoxia-activatable phototherapeutic polymeric prodrug system with a high potential for cancer therapy.
Angewandte Chemie International Edition
This is the peer reviewed version of the following article: Cui, D., Huang, J., Zhen, X., Li, J., Jiang, Y., & Pu, K. (2019). A semiconducting polymer nano‐prodrug for hypoxia‐activated photodynamic cancer therapy. Angewandte Chemie, 131(18), 5981-5985, which has been published in final form at https://doi.org/10.1002/ange.201814730. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.