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Title: Mechanistic formation of drug-encapsulated Janus particles through emulsion solvent evaporation
Authors: Fan, Yan Liang
Tan, Chuan Hao
Lui, Yuansiang
Zudhistira, Dionaldo
Loo, Joachim Say Chye
Keywords: Emulsion
Issue Date: 2018
Source: Fan, Y. L., Tan, C. H., Lui, Y., Zudhistira, D., & Loo, J. S. C. (2018). Mechanistic formation of drug-encapsulated Janus particles through emulsion solvent evaporation. RSC Advances, 8(29), 16032-16042. doi:10.1039/C8RA02271B
Series/Report no.: RSC Advances
Abstract: Janus particles are emerging as structurally unique drug carriers with the potential to deliver multiple drugs and agents. Although synthesis methods have been extensively explored to fabricate Janus particles, it remains a challenge to generate drug-loaded Janus particles through an economical, high throughput technique. Here, we report the formation of the first drug-loaded, micro-scale Janus particles prepared using a single-step emulsion solvent evaporation approach. Our results revealed that both the net charge of drug molecules (i.e. glibenclamide, tolbutamine, rapamycin and lidocaine) and polymer weight ratio (i.e. poly(lactic-co-glycolic) and polycaprolactone) were critical in determining the formation of Janus particles. The formation of drug-loaded Janus particles was proven to be thermodynamically-driven in accordance to the classical equilibrium spreading coefficient theory, which is strongly governed by interfacial tensions. Specifically, comparable interfacial tensions between the two interacting polymers with the water phase were identified to be key criteria to achieve the Janus particles hemispheric structure. Such interfacial tensions were amenable, and were found to be highly dependent on the interfacial charge density attributed to both drug and polymer ratio. Hereby, this study provides a mechanistic insight into the fabrication of drug-loaded Janus particles and paves an important path towards large-scale production of Janus particles using a simplified, single-step emulsion solvent evaporation strategy.
Rights: © 2018 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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