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|Title:||Self-propelled autonomous Mg/Pt janus micromotor interaction with human cells||Authors:||Kong, Lei
Chia, Hui Ling
Nur Farhanah Rosli
|Issue Date:||2019||Source:||Kong, L., Nur Farhanah Rosli., Chia, H. L., Guan, J., & Pumera, M. (2019). Self-propelled autonomous Mg/Pt janus micromotor interaction with human cells. Bulletin of the Chemical Society of Japan, 92(10), 1754-1758. doi:10.1246/bcsj.20190104||Series/Report no.:||Bulletin of the Chemical Society of Japan||Abstract:||Magnesium (Mg)-based micromotors have attracted considerable attention as they are capable of moving in water and human blood plasma without external fuels. It has also been demonstrated that they have potential for drug delivery in mouse stomach. However, their biocompatibility and cytotoxicity to human cells have yet to be studied. Therefore, we performed cytotoxicity study of Mg/Pt Janus micromotors with human lung carcinoma epithelial cells (A549), human breast cancer cells (MCF-7), human embryonic kidney cells (HEK-293), human liver carcinoma cells (HepG2) and human cervical cancer cells (HeLa). The highest concentration of micromotors tested, 200 µg mL−1, drastically induced a high toxic effect on the cells and reduced the cell viability to below 60%. This shows while Pt/Au nanomachines were found to be safe previously, this is not the case of the Mg/Pt micromachines.||URI:||https://hdl.handle.net/10356/104698
|ISSN:||0009-2673||DOI:||http://dx.doi.org/10.1246/bcsj.20190104||Rights:||© 2019 The Chemical Society of Japan. All rights reserved.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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