A high-dimensional, stochastic model for twin-screw granulation – part 1: model description
McGuire, Andrew D.
Lee, Kok Foong
Date of Issue2018
School of Chemical and Biomedical Engineering
In this work we present a novel four-dimensional, stochastic population balance model for twin-screw granulation. The model uses a compartmental framework to reflect changes in mechanistic rates between different screw element geometries. This allows us to capture the evolution of the material along the barrel length. The predictive power of the model is assessed across a range of liquid-solid feed ratios through comparison with experimental particle size distributions. The model results show a qualitative agreement with experimental trends and a number of areas for model improvement are discussed. A sensitivity analysis is carried out to assess the effect of key operating variables and model parameters on the simulated product particle size distribution. The stochastic treatment of the model allows the particle description to be readily extended to track more complex particle properties and their transformations.
Chemical Engineering Science
© 2018 Elsevier. All rights reserved. This paper was published in Chemical Engineering Science and is made available with permission of Elsevier.