Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/81401
Title: Enhanced contrast acoustic-resolution photoacoustic microscopy using double-stage delay-multiply-and-sum beamformer for vasculature imaging
Authors: Mozaffarzadeh, Moein
Varnosfaderani, Mehdi Haji Heidari
Sharma, Arunima
Pramanik, Manojit
de Jong, Nico
Verweij, Martin D.
Keywords: Engineering::Chemical engineering::Biochemical engineering
Acoustic-resolution Photoacoustic Microscopy
Contrast Enhancement
Issue Date: 2019
Source: Mozaffarzadeh, M., Varnosfaderani, M. H. H., Sharma, A., Pramanik, M., de Jong, N., & Verweij, M. D. (2019). Enhanced contrast acoustic-resolution photoacoustic microscopy using double-stage delay-multiply-and-sum beamformer for vasculature imaging. Journal of Biophotonics, 12(11). doi:10.1002/jbio.201900133
Series/Report no.: Journal of Biophotonics
Abstract: In acoustic‐resolution photoacoustic microscopy (AR‐PAM) systems, the lateral resolution in the focal zone of the ultrasound (US) transducer is determined by the numerical aperture (NA) of the transducer. To have a high lateral resolution, a large NA is used. However, the larger the NA, the smaller the depth of focus [DOF]. As a result, the lateral resolution is deteriorated at depths out of the focal region. The synthetic aperture focusing technique (SAFT) along with a beamformer can be used to improve the resolution outside the focal region. In this work, for image formation in AR‐PAM, we propose the double‐stage delay‐multiply‐and‐sum (DS_DMAS) algorithm to be combined with SAFT. The proposed method is evaluated experimentally using hair targets and in vivo vasculature imaging. It is shown that DS_DMAS provides a higher resolution and contrast compared to other methods. For the B‐mode images obtained using the hair phantom, the proposed method reduces the average noise level for all the depths by about 134%, 57% and 23%, compared to the original low‐ resolution, SAFT+DAS and SAFT+DMAS methods, respectively. All the results indicate that the proposed method can be an appropriate algorithm for image formation in AR‐PAM systems.
URI: https://hdl.handle.net/10356/81401
http://hdl.handle.net/10220/50390
ISSN: 1864-063X
DOI: https://doi.org/10.1002/jbio.201900133
Rights: This is the peer reviewed version of the following article: Mozaffarzadeh, M., Varnosfaderani, M. H. H., Sharma, A., Pramanik, M., de Jong, N., & Verweij, M. D. (2019). Enhanced contrast acoustic-resolution photoacoustic microscopy using double-stage delay-multiply-and-sum beamformer for vasculature imaging. Journal of Biophotonics, 12(11). doi:10.1002/jbio.201900133, which has been published in final form at https://doi.org/10.1002/jbio.201900133. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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