Recent Submissions

  • Binding modes of teixobactin to lipid ii : molecular dynamics study 

    Liu, Yang; Liu, Yaxin; Chan-Park, Mary Bee Eng; Mu, Yuguang (2017)
    Teixobactin (TXB) is a newly discovered antibiotic targeting the bacterial cell wall precursor Lipid II (LII). In the present work, four binding modes of TXB on LII were identified by a contact-map based clustering method. ...
  • Diffusion and distribution of deuterium in scandium deuteride thin films under irradiation of deuterium ion beam 

    Wang, Tao; Long, Jidong; Wang, Shiwei; Yang, Zhen; Li, Jie; Huang, Gang; Zhang, Linwen; Yang, Allen Jian; Wang, Xiao Renshaw (2017)
    Scandium deuteride (ScDx) thin films, as an alternative target for deuterium-deuterium (D-D) reaction, are a very important candidate for detection and diagnostic applications. Albeit with their superior thermal stability, ...
  • The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma 

    Zhai, Weiwei; Lim, Tony Kiat-Hon; Zhang, Tong; Phang, Su-Ting; Tiang, Zenia; Guan, Peiyong; Ng, Ming-Hwee; Lim, Jia Qi; Yao, Fei; Li, Zheng; Ng, Poh Yong; Yan, Jie; Goh, Brian K.; Chung, Alexander Yaw-Fui; Choo, Su-Pin; Khor, Chiea Chuen; Soon, Wendy Wei-Jia; Sung, Ken Wing-Kin; Foo, Roger Sik-Yin; Chow, Pierce Kah-Hoe (2017)
    Hepatocellular carcinoma (HCC) has one of the poorest survival rates among cancers. Using multi-regional sampling of nine resected HCC with different aetiologies, here we construct phylogenetic relationships of these ...
  • Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation 

    Kalailingam, Pazhanichamy; Tan, Hui Bing; Jain, Neeraj; Sng, Ming Keat; Chan, Jeremy Soon Kiat; Tan, Nguan Soon; Thanabalu, Thirumaran (2017)
    Neural-Wiskott Aldrich Syndrome Protein (N-WASP) is expressed ubiquitously and regulates actin cytoskeleton remodeling. In order to characterize the role of N-WASP in epidermal homeostasis and cutaneous biology, we generated ...
  • Characterizing the conformational landscape of MDM2-binding p53 peptides using molecular dynamics simulations 

    Yadahalli, Shilpa; Li, Jianguo; Lane, David P.; Gosavi, Shachi; Verma, Chandra Shekhar (2017)
    The conformational landscapes of p53 peptide variants and phage derived peptide (12/1) variants, all known to bind to MDM2, are studied using hamiltonian replica exchange molecular dynamics simulations. Complementing earlier ...
  • Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen expression 

    Teo, Ziqiang; Chan, Jeremy Soon Kiat; Chong, Han Chung; Sng, Ming Keat; Choo, Chee Chong; Phua, Glendon Zhi Ming; Teo, Daniel Jin Rong; Zhu, Pengcheng; Choong, Cleo; Wong, Marcus Thien Chong; Tan, Nguan Soon (2017)
    In adult skin wounds, collagen expression rapidly re-establishes the skin barrier, although the resultant scar is aesthetically and functionally inferior to unwounded tissue. Although TGFβ signaling and fibroblasts are ...
  • Zeeman splitting via spin-valley-layer coupling in bilayer MoTe2 

    Jiang, Chongyun; Liu, Fucai; Cuadra, Jorge; Huang, Zumeng; Li, Ke; Rasmita, Abdullah; Srivastava, Ajit; Liu, Zheng; Gao, Wei-Bo (2017)
    Atomically thin monolayer transition metal dichalcogenides possess coupling of spin and valley degrees of freedom. The chirality is locked to identical valleys as a consequence of spin–orbit coupling and inversion symmetry ...
  • Benchmarking selected computational gene network growing tools in context of virus-host interactions 

    Taye, Biruhalem; Vaz, Candida; Tanavde, Vivek; Kuznetsov, Vladimir A.; Eisenhaber, Frank; Sugrue, Richard J; Maurer-Stroh, Sebastian (2017)
    Several available online tools provide network growing functions where an algorithm utilizing different data sources suggests additional genes/proteins that should connect an input gene set into functionally meaningful ...
  • Bi-directional high speed domain wall motion in perpendicular magnetic anisotropy Co/Pt double stack structures 

    Sethi, Pankaj; Krishnia, Sachin; Gan, Weiliang; Kholid, Farhan N.; Tan, Funan; Maddu, Ramu; Lew, Wen Siang (2017)
    We report bi-directional domain wall (DW) motion along and against current flow direction in Co/Pt double stack wires with Ta capping. The bi-directionality is achieved by application of hard-axis magnetic field favoring ...
  • Cat-D: a targeted sequencing method for the simultaneous detection of small DNA mutations and large DNA deletions with flexible boundaries 

    Hong, Ru; Chandola, Udita; Zhang, Li-Feng (2017)
    We developed a targeted DNA sequencing method that is capable of detecting a comprehensive panel of DNA mutations including small DNA mutations and large DNA deletions with unknown/flexible boundaries. The method directly ...
  • Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation 

    Davey, Gabriela Elzbieta; Adhireksan, Zenita; Ma, Zhujun; Riedel, Tina; Sharma, Deepti; Padavattan, Sivaraman; Rhodes, Daniela; Ludwig, Alexander; Sandin, Sara; Murray, Benjamin S.; Dyson, Paul J.; Davey, Curtis Alexander (2017)
    The ‘acidic patch’ is a highly electronegative cleft on the histone H2A–H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially ...
  • Room-temperature 2D semiconductor activated vertical-cavity surface-emitting lasers 

    Shang, Jingzhi; Cong, Chunxiao; Wang, Zilong; Peimyoo, Namphung; Wu, Lishu; Zou, Chenji; Chen, Yu; Chin, Xin Yu; Wang, Jianpu; Soci, Cesare; Huang, Wei; Yu, Ting (2017)
    Two-dimensional (2D) semiconductors are opening a new platform for revitalizing widely spread optoelectronic applications. The realisation of room-temperature vertical 2D lasing from monolayer semiconductors is fundamentally ...
  • Oriented graphene nanoribbons embedded in hexagonal boron nitride trenches 

    Chen, Lingxiu; He, Li; Wang, Hui Shan; Wang, Haomin; Tang, Shujie; Cong, Chunxiao; Xie, Hong; Li, Lei; Xia, Hui; Li, Tianxin; Wu, Tianru; Zhang, Daoli; Deng, Lianwen; Yu, Ting; Xie, Xiaoming; Jiang, Mianheng (2017)
    Graphene nanoribbons (GNRs) are ultra-narrow strips of graphene that have the potential to be used in high-performance graphene-based semiconductor electronics. However, controlled growth of GNRs on dielectric substrates ...
  • Hot carrier cooling mechanisms in halide perovskites 

    Fu, Jianhui; Xu, Qiang; Han, Guifang; Wu, Bo; Huan, Cheng Hon Alfred; Leek, Meng Lee; Sum, Tze Chien (2017)
    Halide perovskites exhibit unique slow hot-carrier cooling properties capable of unlocking disruptive perovskite photon–electron conversion technologies (e.g., high-efficiency hot-carrier photovoltaics, photo-catalysis, ...
  • IgG1 memory B cells keep the memory of IgE responses 

    He, Jin-Shu; Subramaniam, Sharrada; Narang, Vipin; Srinivasan, Kandhadayar; Saunders, Sean P.; Carbajo, Daniel; Wen-Shan, Tsao; Hidayah Hamadee, Nur; Lum, Josephine; Lee, Andrea; Chen, Jinmiao; Poidinger, Michael; Zolezzi, Francesca; Lafaille, Juan J.; Curotto de Lafaille, Maria A. (2017)
    The unique differentiation of IgE cells suggests unconventional mechanisms of IgE memory. IgE germinal centre cells are transient, most IgE cells are plasma cells, and high affinity IgE is produced by the switching of IgG1 ...
  • Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy 

    Reza, Musarrat Maisha; Subramaniyam, Nathiya; Sim, Chu Ming; Ge, Xiaojia; Sathiakumar, Durgalakshmi; McFarlane, Craig; Sharma, Mridula; Kambadur, Ravi (2017)
    Exercise induces expression of the myokine irisin, which is known to promote browning of white adipose tissue and has been shown to mediate beneficial effects following exercise. Here we show that irisin induces expression ...
  • Thermodynamics of hairy black holes in Lovelock gravity 

    Hennigar, Robie A.; Tjoa, Erickson; Mann, Robert B. (2017)
    We perform a thorough study of the thermodynamic properties of a class of Lovelock black holes with conformal scalar hair arising from coupling of a real scalar field to the dimensionally extended Euler densities. We study ...
  • Gravitation and quadratic forms 

    Ananth, Sudarshan; Brink, Lars; Majumdar, Sucheta; Mali, Mahendra; Shah, Nabha (2017)
    The light-cone Hamiltonians describing both pure ( N = 0) Yang-Mills and N = 4 super Yang-Mills may be expressed as quadratic forms. Here, we show that this feature extends to theories of gravity. We demonstrate how ...
  • Aza-bridged bisphenanthrolinyl Pt(ii) complexes : efficient stabilization and topological selectivity on telomeric G-quadruplexes 

    He, Lei; Meng, Zhenyu; Xie, Yi-qun; Chen, Xiang; Li, Tianhu; Shao, Fangwei (2017)
    Two platinum complexes with an aza-bridged bis(1,10-phenanthrolin-2-yl)amine (bpa) were synthesized. The two phenanthrolines in bpa entered a flat plane prior to binding of nucleic acids, which bestowed on the two Pt ...
  • Transformable masks for colloidal nanosynthesis 

    Wang, Zhenxing; He, Bowen; Xu, Gefei; Wang, Guojing; Wang, Jiayi; Feng, Yuhua; Su, Dongmeng; Chen, Bo; Li, Hai; Wu, Zhonghua; Zhang, Hua; Shao, Lu; Chen, Hongyu (2018)
    Synthetic skills are the prerequisite and foundation for the modern chemical and pharmaceutical industry. The same is true for nanotechnology, whose development has been hindered by the sluggish advance of its synthetic ...

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