Recent Submissions

  • Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment 

    Cheng, Hong Sheng; Lee, Jeannie Xue Ting; Wahli, Walter; Tan, Nguan Soon (2019)
    The tumor microenvironment is a complex and dynamic cellular community comprising the tumor epithelium and various tumor-supporting cells such as immune cells, fibroblasts, immunosuppressive cells, adipose cells, endothelial ...
  • Agglomeration of nano- and microplastic particles in seawater by autochthonous and de novo-produced sources of exopolymeric substances 

    Summers, Stephen; Henry, Theodore; Gutierrez, Tony (2018)
    Microplastics (<5 mm) have often been studied under in-vitro conditions where plastics have been investigated in isolation. However, in the natural environment microplastics readily form agglomerates conferring the particles ...
  • Full-genome sequence of Thalassotalea euphylliae H1, isolated from a Montipora capitata coral located in Hawai’i 

    Summers, Stephen; Freckelton, Marnie L.; Nedved, Brian T.; Rice, Scott A.; Hadfield, Michael G. (2018)
    The isolate of Thalassotalea euphylliae H1 was collected from the surface of a Montipora capitata coral. The genome was assembled using long reads from a Nanopore MinION sequencer for scaffolding and complemented with ...
  • Complete genome sequence of Thalassotalea euphylliae strain H2 

    Summers, Stephen; Freckelton, Marnie L.; Nedved, Brian T.; Rice, Scott A.; Hadfield, Michael G. (2019)
    A bacterial isolate of Thalassotalea euphylliae H2 was collected from the coral Montipora capitata. MinION long reads were employed for scaffolding and complemented with short-read MiSeq sequences to permit complete ...
  • Draft genome sequence of Enterobacter sp. strain EA-1, an electrochemically active microorganism isolated from tropical sediment 

    Doyle, Lucinda Elizabeth; Williams, Rohan Benjamin Hugh; Rice, Scott A.; Marsili, Enrico; Lauro, Federico M. (2018)
    Enterobacter sp. EA-1 is an electrochemically-active bacterium isolated from tropical sediment in Singapore. Here, the annotated draft genome assembly is reported. Whole genome comparison indicates sp. EA-1, along with a ...
  • Phosphatidylserine synthesis is essential for viability of the human fungal pathogen Cryptococcus neoformans 

    Konarzewska, Paulina; Wang, Yina; Han, Gil-Soo; Goh, Kwok Jian; Gao, Yong-Gui; Carman, George M.; Xue, Chaoyang (2019)
    Phospholipids are an integral part of the cellular membrane structure and can be produced by a de novo biosynthetic pathway and, alternatively, by the Kennedy pathway. Studies in several yeast species have shown that the ...
  • Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01 

    Gu, Yue; Wong, Yee Hwa; Liew, Chong Wai; Chan, Conrad E. Z.; Murali, Tanusya M.; Yap, Jiawei; Too, Chien Tei; Purushotorman, Kiren; Hamidinia, Maryam; El Sahili, Abbas; Goh, Angeline T. H.; Teo, Rachel Z. C.; Wood, Kathryn J.; Hanson, Brendon J.; Gascoigne, Nicholas R. J.; Lescar, Julien; Vathsala, Anantharaman; MacAry, Paul A. (2019)
    Our understanding of the conformational and electrostatic determinants that underlie targeting of human leukocyte antigens (HLA) by anti-HLA alloantibodies is principally based upon in silico modelling. Here we provide a ...
  • Kingdom-wide comparison reveals the evolution of diurnal gene expression in Archaeplastida 

    Ferrari, Camilla; Proost, Sebastian; Janowski, Marcin; Becker, Jörg; Nikoloski, Zoran; Bhattacharya, Debashish; Price, Dana; Tohge, Takayuki; Bar-Even, Arren; Fernie, Alisdair; Stitt, Mark; Mutwil, Marek (2019)
    Plants have adapted to the diurnal light-dark cycle by establishing elaborate transcriptional programs that coordinate many metabolic, physiological, and developmental responses to the external environment. These transcriptional ...
  • Mapping of γ/δ t cells reveals vδ2+ t cells resistance to senescence 

    Xu, Weili; Monaco, Gianni; Wong, Eleanor Huijin; Tan, Wilson Lek Wen; Kared, Hassen; Simoni, Yannick; Tan, Shu Wen; How, Wilson Zhi Yong; Tan, Crystal Tze Ying; Lee, Bernett Teck Kwong; Carbajo, Daniel; K.G., Srinivasan; Low, Ivy Chay Huang; Mok, Esther Wing Hei; Foo, Shihui; Lum, Josephine; Tey, Hong Liang; Tan, Wee Ping; Poidinger, Michael; Newell, Evan; Ng, Tze Pin; Foo, Roger; Akbar, Arne N.; Fülöp, Tamas; Larbi, Anis (2019)
    Background: Immune adaptation with aging is a major of health outcomes. Studies in humans have mainly focus on αβ T cells while γδ T cells have been neglected despite their role in immunosurveillance. We investigated the ...
  • tRNA epitranscriptomics and biased codon are linked to proteome expression in Plasmodium falciparum 

    Ng, Chee Sheng; Sinha, Ameya; Aniweh, Yaw; Nah, Qianhui; Babu, Indrakanti Ramesh; Gu, Chen; Chionh, Yok Hian; Dedon, Peter C.; Preiser, Peter Rainer (2018)
    Among components of the translational machinery, ribonucleoside modifications on tRNAs are emerging as critical regulators of cell physiology and stress response. Here, we demonstrate highly coordinated behavior of the ...
  • The phase separation underlying the pyrenoid-based microalgal Rubisco supercharger 

    Wunder, Tobias; Cheng, Steven Le Hung; Lai, Soak-Kuan; Li, Hoi-Yeung; Mueller-Cajar, Oliver (2018)
    The slow and promiscuous properties of the CO2-fixing enzyme Rubisco constrain photosynthetic efficiency and have prompted the evolution of powerful CO2 concentrating mechanisms (CCMs). In eukaryotic microalgae a key ...
  • The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background 

    Zhu, Lei; Tripathi, Jaishree; Rocamora, Frances Maureen; Miotto, Olivo; van der Pluijm, Rob; Voss, Till S.; Mok, Sachel; Kwiatkowski, Dominic P.; Nosten, François; Day, Nicholas P. J.; White, Nicholas J.; Dondorp, Arjen M.; Bozdech, Zbynek (2018)
    The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To explore the chain of casualty underlying ...
  • Structural basis of RIP2 activation and signaling 

    Gong, Qin; Long, Ziqi; Zhong, Franklin L.; Teo, Daniel Eng Thiam; Jin, Yibo; Yin, Zhan; Boo, Zhao Zhi; Zhang, Yaming; Zhang, Jiawen; Yang, Renliang; Bhushan, Shashi; Reversade, Bruno; Li, Zongli; Wu, Bin (2018)
    Signals arising from bacterial infections are detected by pathogen recognition receptors (PRRs) and are transduced by specialized adapter proteins in mammalian cells. The Receptor-interacting-serine/threonine-protein kinase ...
  • Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5 

    Shi, Meng; Chen, Bing; Mahajan, Divyanshu; Boh, Boon Kim; Zhou, Yan; Dutta, Bamaprasad; Tie, Hieng Chiong; Sze, Siu Kwan; Wu, Geng; Lu, Lei (2018)
    The endosome-to-Golgi or endocytic retrograde trafficking pathway is an important post-Golgi recycling route. Here we show that amino acids (AAs) can stimulate the retrograde trafficking and regulate the cell surface ...
  • Lipopolysaccharide-affinity copolymer senses the rapid motility of swarmer bacteria to trigger antimicrobial drug release 

    Lu, Shengtao; Bi, Wuguo; Du, Quanchao; Sinha, Sheetal; Wu, Xiangyang; Subrata, Arnold; Bhattacharjya, Surajit; Xing, Bengang; Yeow, Edwin Kok Lee (2018)
    An intelligent drug release system that is triggered into action upon sensing the motion of swarmer P. mirabilis is introduced. The rational design of the drug release system focuses on a pNIPAAm-co-pAEMA copolymer that ...
  • Inducing ischemia-reperfusion injury in the mouse ear skin for intravital multiphoton imaging of immune responses 

    Goh, Chi Ching; Li, Jackson LiangYao; Becker, David; Weninger, Wolfgang; Angeli, Veronique; Ng, Lai Guan (2016)
    Ischemia-reperfusion injury (IRI) occurs when there is transient hypoxia due to the obstruction of blood flow (ischemia) followed by a subsequent re-oxygenation of the tissues (reperfusion). In the skin, ischemia-reperfusion ...
  • Ginsentides : cysteine and glycine-rich peptides from the ginseng family with unusual disulfide connectivity 

    Tam, James P.; Nguyen, Giang Kien Truc; Loo, Shining; Wang, Shujing; Yang, Daiwen; Kam, Antony (2018)
    Ginseng, a popular and valuable traditional medicine, has been used for centuries to maintain health and treat disease. Here we report the discovery and characterization of ginsentides, a novel family of cysteine and ...
  • Construction sites as an important driver of dengue transmission: implications for disease control 

    Liang, Shaohong; Hapuarachchi, Hapuarachchige Chanditha; Rajarethinam, Jayanthi; Koo, Carmen; Tang, Choon-Siang; Chong, Chee-Seng; Ng, Lee-Ching; Yap, Grace (2018)
    Background:In 2013 and 2014, Singapore experienced its worst dengue outbreak known-to-date. Mosquito breeding in construction sites stood out as a probable risk factor due to its association with major dengue clusters in ...
  • Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway 

    Ye, Weijian; Chew, Marvin; Hou, Jue; Lai, Fritz; Leopold, Stije J.; Loo, Hooi Linn; Ghose, Aniruddha; Dutta, Ashok K.; Chen, Qingfeng; Ooi, Eng Eong; White, Nicholas J.; Dondorp, Arjen M.; Preiser, Peter; Chen, Jianzhu (2018)
    Natural killer (NK) cells provide the first line of defense against malaria parasite infection. However, the molecular mechanisms through which NK cells are activated by parasites are largely unknown, so is the molecular ...
  • Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents 

    Yuan, Mingjun; Chua, Song Lin; Liu, Yang; Drautz-Moses, Daniela Isabel; Yam, Joey Kuok Hoong; Aung, Thet Tun; Beuerman, Roger W.; Salido, May Margarette Santillan; Schuster, Stephan Christoph; Tan, Choon-Hong; Givskov, Michael; Yang, Liang; Nielsen, Thomas Eiland (2018)
    Antibiotic resistance threatens effective treatment of microbial infections globally. This situation has spurred the hunt for new antimicrobial compounds in both academia and the pharmaceutical industry. Here, we report ...

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