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|Title:||Collective cell migration on artificial extracellular matrix proteins containing full-length fibronectin domains||Authors:||Fong, Eileen.
Tirrell, David A.
|Keywords:||DRNTU::Engineering::Materials::Biomaterials||Issue Date:||2010||Source:||Fong, E., & Tirrell, D. A. (2010). Collective Cell Migration on Artificial Extracellular Matrix Proteins Containing Full-Length Fibronectin Domains. Advanced Materials, 22, 5271-5275.||Series/Report no.:||Advanced materials||Abstract:||The discovery of the cell-adhesive properties of the Arg-Gly-Asp (RGD) sequence located in the tenth type III domain of fi bronectin triggered widespread use of RGD-functionalized materials for directing cell behavior. [ 1,2 ] In studies of cell adhesion and migration, however, cell responses on RGD surfaces are never identical to those observed on fi bronectin. [ 3 ] For example, we recently examined the attachment and patterning of Rat-1 fi broblasts on elastin-based artifi cial extracellular matrix (aECM) proteins bearing a fi bronectin-derived RGD sequence and found the average projected area of such cells to be approximately 60% of those spread on fi bronectin.||URI:||https://hdl.handle.net/10356/85262
|DOI:||10.1002/adma.201002448||Rights:||© 2010 Wiley-VCH Verlag.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||MSE Journal Articles|
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