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Title: Collective cell migration on artificial extracellular matrix proteins containing full-length fibronectin domains
Authors: Fong, Eileen.
Tirrell, David A.
Keywords: DRNTU::Engineering::Materials::Biomaterials
Issue Date: 2010
Source: Fong, E., & Tirrell, D. A. (2010). Collective Cell Migration on Artificial Extracellular Matrix Proteins Containing Full-Length Fibronectin Domains. Advanced Materials, 22, 5271-5275.
Series/Report no.: Advanced materials
Abstract: The discovery of the cell-adhesive properties of the Arg-Gly-Asp (RGD) sequence located in the tenth type III domain of fi bronectin triggered widespread use of RGD-functionalized materials for directing cell behavior. [ 1,2 ] In studies of cell adhesion and migration, however, cell responses on RGD surfaces are never identical to those observed on fi bronectin. [ 3 ] For example, we recently examined the attachment and patterning of Rat-1 fi broblasts on elastin-based artifi cial extracellular matrix (aECM) proteins bearing a fi bronectin-derived RGD sequence and found the average projected area of such cells to be approximately 60% of those spread on fi bronectin.
DOI: 10.1002/adma.201002448
Rights: © 2010 Wiley-VCH Verlag.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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