Supramolecular assembly of gold nanoparticles mediated by polypseudorotaxane with thiolated β-cyclodextrin

Abstract

A water-soluble gold nanoparticle aggregate 2 was prepared by chloroauric acid and a polypseudorotaxane 1 of mono-6-thio-β-cyclodextrin with poly(propylene glycol) bis(2-aminopropyl ether) (M ̅_w ≈2000) in the presence of sodium borohydride in N,N-dimethylformamide (DMF) solution. The investigative results indicated that the gold nanoparticle aggregate 2 might act as an efficient DNA-cleavage reagent.