Self-assembly behavior of inclusion complex formed by β-cyclodextrin with α-aminopyridine
Date of Issue2004
An inclusion complex (1) has been prepared by β-cyclodextrin with α-aminopyridine The result of X-ray crystallographic analyses showed that the α-aminopyridine molecules in the β-cyclodextrin cavities possess two opposite orientations, i.e. the amine group of α-aminopyridine pointing to the primary side (1a, occupancy: 41.2%) or the secondary side (1b, occupancy: 58.8%) of β-cyclodextrin, forming two scalelike supramolecular aggregations. The studies of 2D NMR and circular dichroism spectra indicated that the α-aminopyridine molecule is deeply embedded in the β-cyclodextrin cavity to form host-guest inclusion complex, showing a circular dichroism spectrum induced by the chiral cavity of cyclodextrin. The results obtained are helpful for understanding the molecular recognition and aggregation mechanism between the host and guest.
Science in China series B - chemistry
© 2004 Science in China Press. This is the author created version of a work that has been peer reviewed and accepted for publication by Science in China series B - chemistry, Science in China Press. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: http://www.springerlink.com/content/595768t167173711/.