Optimization of isocratic supercritical fluid chromatography for enantiomer separation
Date of Issue2010
School of Chemical and Biomedical Engineering
This paper presents multi-objective optimization analysis and experimental implementation of a single column isocratic supercritical fluid chromatography process for the enantioseparation of flurbiprofen. The single column process is simulated using a detailed model with equilibrium description by a competitive Langmuir isotherm. The optimization problem has been formulated with the objectives of maximizing of productivity and minimizing solvent consumption under different product purity and recovery constraints. The solubility of the solute in the mobile phase is explicitly accounted in the problem formulation. The results showed a maximum productivity of 5 kg racemate/kg stationary phase / day with a corresponding organic solvent consumption of 80 L/kg racemate for a required purity and recovery of 95\%. The optimal operating conditions have been experimentally implemented in an analytical scale laboratory set-up which support the optimization results.
DRNTU::Science::Chemistry::Organic chemistry::Organic chromatography
Journal of chromatography A
© 2010 Elsevier B.V. This is the author created version of a work that has been peer reviewed and accepted for publication by Optimization of isocratic supercritical fluid chromatography for enantiomer separation, Journal of Chromatography A, on behalf of Elsevier B.V. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: http://dx.doi.org/10.1016/j.chroma.2010.10.109.