On DNA modelling : interaction of a double helicoidal structure with viscous bio-fluid
Lim, C. W.
Shu, Jian Jun
Date of Issue2001
School of Mechanical and Aerospace Engineering
City University of Hong Kong
The paper aims at extending, utilising and generalising research in nonlinear dynamics of (i) spiral/helicoidal structures, and (ii) viscous, low speed fluid to biomechanical DNA fluidstructure interaction. Employing a nonlinear helicoidal model, the energy stored in a distorted Watson-Crick DNA model subjected to viscous, low speed organic fluid loading is formulated. Numerical solutions based on the variational principle are presented for a linearized flow field as examples. Significant dynamical responses such as deformation components and resultants are discussed. A proposal for matching of DNA sequential characteristics with respect to the nonlinear dynamical responses is outlined in order to reveal information regarding DNA sequencing by means of a fluid-structure dynamical approach.
© 2001 OPA (Overseas Publishers Association) N.V.