dc.contributor.authorThan, Aung
dc.contributor.authorYe, Feng
dc.contributor.authorXue, Renhao
dc.contributor.authorOng, Jun Wei
dc.contributor.authorPoh, Chueh Loo
dc.contributor.authorChen, Peng
dc.date.accessioned2012-02-14T06:31:26Z
dc.date.available2012-02-14T06:31:26Z
dc.date.copyright2010en_US
dc.date.issued2010
dc.identifier.citationThan, A., Ye, F., Xue, R., Ong, J. W., Poh, C. L. & Chen P. (2011). The Crosstalks Between Adipokines and Catecholamines. Molecular and Cellular Endocrinology, 332(1-2), 261-270.en_US
dc.identifier.urihttp://hdl.handle.net/10220/7521
dc.description.abstractAdipocytes, which secrete a spectrum of adipokines, play an integral role in metabolism via communications with other endocrine cells. In the present work, we have studied the interplays between adipokines and catecholamines, using 3T3-L1 adipocytes and PC12 cells as the cell models and an integrative experimental platform. We demonstrate that all catecholamines inhibit vesicle trafficking and secretion of leptin and resistin through β-adrenergic receptors, while leptin and resistin enhance the vesicle trafficking and secretion of catecholamines through PKC, PKA, MAPK kinase and Ca2+ dependent pathways. The crosstalks between adipokines and catecholamines were further corroborated by co-culturing 3T3-L1 adipocytes and PC12 cells. Our findings highlight the importance of adipo-adrenal axis in energy metabolism and the intricate interactions between metabolic hormones.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesMolecular and cellular endocrinologyen_US
dc.rights© 2010 Elsevier Ireland Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Molecular and Cellular Endocrinology, Elsevier Ireland Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI: http://dx.doi.org/10.1016/j.mce.2010.11.002]en_US
dc.subjectDRNTU::Science::Medicine::Biomedical engineering
dc.titleThe crosstalks between adipokines and catecholaminesen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.mce.2010.11.002
dc.description.versionAccepted versionen_US
dc.identifier.rims163183


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