dc.contributor.authorHuang, Yinxi
dc.contributor.authorDong, Xiaochen
dc.contributor.authorLiu, Yuxin
dc.contributor.authorLi, Lain-Jong
dc.contributor.authorChen, Peng
dc.date.accessioned2012-02-28T07:56:22Z
dc.date.available2012-02-28T07:56:22Z
dc.date.copyright2011en_US
dc.date.issued2011
dc.identifier.citationHuang, Y., Dong, X., Liu, Y., Li, L. J., & Chen, P. (2011). Graphene-based biosensors for detection of bacteria and their metabolic activities. Journal of Materials Chemistry, 21, 12358–12362.en_US
dc.identifier.urihttp://hdl.handle.net/10220/7545
dc.description.abstractGraphene, which is a recently discovered single-atom-thick planar sheet of carbon atoms perfectly arranged in a honeycomb lattice, has great potential in biosensing owing to its extraordinary electrical, physical, and optical properties. In this work, we demonstrate a graphene based biosensor to electrically detect E. coli bacteria with high sensitivity and specificity. The large-sized graphene film was grown by chemical vapor deposition and functionalized with anti-E. coli antibodies and passivation layer. Significant conductance increase of the graphene device was observed after exposure to E. coli bacteria at a concentration as low as 10 cfu/mL, while no significant response was triggered by high concentration of the another bacterial strain. In addition, this biosensor was employed to detect the glucose induced metabolic activities of the bound E. coli bacteria in real time. This simple, fast, sensitive, and label-free nanoelectronic biosensor, in principle, could serve as a high throughput platform for detection of any pathogenic bacteria, and for functional studies or screening of antibacterial drugs.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesJournal of materials chemistryen_US
dc.rights© 2011 The Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Materials Chemistry, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI: http://dx.doi.org/10.1039/c1jm11436k].en_US
dc.subjectDRNTU::Science::Chemistry::Organic chemistry::Antibiotics
dc.titleGraphene-based biosensors for detection of bacteria and their metabolic activitiesen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1039/c1jm11436k
dc.description.versionAccepted versionen_US
dc.identifier.rims163170


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