dc.contributor.authorSun, Yi
dc.contributor.authorKwok, Yien Chian
dc.contributor.authorNguyen, Nam-Trung
dc.identifier.citationSun, Y., Kwok, Y. C., & Nguyen, N. T. (2006). Low-pressure, high-temperature thermal bonding of polymeric microfluidic devices and their applications for electrophoretic separation. Journal of Micromechanics and Microengineering, 16(8).en_US
dc.description.abstractA new method for thermally bonding poly(methyl methacrylate) (PMMA) substrates has been demonstrated. PMMA substrates are first engraved by CO2-laser micromachining to form microchannels. Both channel width and depth can be adjusted by varying the laser power and scanning speed. Channel depths from 50 µm to 1500 µm and widths from 150 µm to 400 µm are attained. CO2 laser is also used for drilling and dicing of the PMMA parts. Considering the thermal properties of PMMA, a novel thermal bonding process with high temperature and low bonding pressure has been developed for assembling PMMA sheets. A high bonding strength of 2.15 MPa is achieved. Subsequent inspection of the cross sections of several microdevices reveals that the dimensions of the channels are well preserved during the bonding process. Electroosmotic mobility of the ablated channel is measured to be 2.47 × 10−4 cm2 V−1 s−1. The functionality of these thermally bonded microfluidic substrates is demonstrated by performing rapid and high-resolution electrophoretic separations of mixture of fluorescein and carboxyfluorescein as well as double-stranded DNA ladders (ΦX174-Hae III dsDNA digest). The performance of the CO2 laser ablated and thermally bonded PMMA devices compares favorably with those fabricated by other professional means.en_US
dc.format.extent22 p.en_US
dc.relation.ispartofseriesJournal of micromechanics and microengineeringen_US
dc.rights© 2006 IOP Publishing Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of micromechanics and microengineering, IOP Publishing Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI: http://dx.doi.org/ 10.1088/0960-1317/16/8/033 ].en_US
dc.subjectDRNTU::Engineering::Mechanical engineering
dc.titleLow-pressure, high-temperature thermal bonding of polymeric microfluidic devices and their applications for electrophoretic separationen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.identifier.doihttp://dx.doi.org/ 10.1088/0960-1317/16/8/033
dc.description.versionAccepted version

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