Enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes
Chi, Robin Yonggui
Date of Issue2012
School of Physical and Mathematical Sciences
An enantioselective and direct oxidative coupling of aldehydes to tertiary amines to give β-amino alcohols is described. Catalyzed by copper(II), the reaction proceeds to give a racemic mixture of products; however, by using a combination of copper(II) and a chiral amine catalyst, the reaction gives the desired products with high enantioselectivity.
Angewandte chemie international edition
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.