Facile access to chiral ketones through metal-free oxidative C-C bond cleavage of aldehydes by O2
Chi, Robin Yonggui
Date of Issue2012
School of Physical and Mathematical Sciences
Giving the metal the boot: The title reaction provides facile access to functionalized chiral ketones from chiral α,α′-disubstituted aldehydes in the presence of molecular oxygen (see scheme). The CC bond-cleavage approach offers an alternative or better method relative to the typical bond-forming strategies used in synthesizing chiral ketones.
DRNTU::Engineering::Chemical engineering::Biochemical engineering
Angewandte chemie international edition
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