Brønsted acid catalyzed α-alkylation of aldehydes with diaryl methyl alcohols
Chi, Robin Yonggui
Date of Issue2011
School of Physical and Mathematical Sciences
A proton does the two jobs: Brønsted acids alone catalyze the α-alkylation of aldehydes with diaryl alcohols. In this type of transformation, the acid-catalysis approach offers a broader substrate scope compared to the previously used enamine catalysis methods. The acid plays two important roles: one is to mediate the alcohol dehydration for carbocation formation; the other is to accelerate the rate-determining aldehyde enolization.
Chemistry - a European journal
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