dc.contributor.authorZhu, Pengcheng
dc.contributor.authorTan, Ming Jie
dc.contributor.authorHuang, Royston-Luke
dc.contributor.authorTan, Chek Kun
dc.contributor.authorChong, Han Chung
dc.contributor.authorPal, Mintu
dc.contributor.authorLam, Ivan Chee Ren
dc.contributor.authorBoukamp, Petra
dc.contributor.authorPan, Jiun Yit
dc.contributor.authorTan, Suat Hoon
dc.contributor.authorKersten, Sander
dc.contributor.authorLi, Hoi-Yeung
dc.contributor.authorDing, Jeak Ling
dc.contributor.authorTan, Nguan Soon
dc.identifier.citationZhu, P., Tan, M. J., Huang, R. L., Tan, C. K., Chong, H. C., Pal, M., et al. (2011). Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2(-): H2O2 Ratio and Confers Anoikis Resistance to Tumors. Cancer cell, 19(3), 401-415.en_US
dc.description.abstractCancer is a leading cause of death worldwide. Tumor cells exploit various signaling pathways to promote their growth and metastasis. To our knowledge, the role of angiopoietin-like 4 protein (ANGPTL4) in cancer remains undefined. Here, we found that elevated ANGPTL4 expression is widespread in tumors, and its suppression impairs tumor growth associated with enhanced apoptosis. Tumor-derived ANGPTL4 interacts with integrins to stimulate NADPH oxidase-dependent production of O2(-). A high ratio of O2:(-)H2O2 oxidizes/activates Src, triggering the PI3K/PKBα and ERK prosurvival pathways to confer anoikis resistance, thus promoting tumor growth. ANGPTL4 deficiency results in diminished O2(-) production and a reduced O2:(-)H2O2 ratio, creating a cellular environment conducive to apoptosis. ANGPTL4 is an important redox player in cancer and a potential therapeutic target.en_US
dc.format.extent15 p.en_US
dc.relation.ispartofseriesCancer cellen_US
dc.rights© 2011 Elsevier Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Cancer Cell, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI: http://dx.doi.org/10.1016/j.ccr.2011.01.018 ]en_US
dc.subjectDRNTU::Science::Biological sciences::Cytology
dc.titleAngiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumorsen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US

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