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https://hdl.handle.net/10356/95496
Title: | X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death | Authors: | Yoon, Ho Sup Sattler, Michael Muchmore, Steven W. Liang, Heng Meadows, Robert P. Harlan, John E. Nettesheim, David G. Chang, Brian S. Thompson, Craig B. Wong, Sui-Lam Ng, Shi-Chung Fesik, Stephen W. |
Keywords: | DRNTU::Science::Biological sciences | Issue Date: | 1996 | Source: | Muchmore, S. W., Sattler, M., Liang, H., Meadows, R. P., Harlan, J. E., Yoon, H. S., et al. (1996). X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature, 381, 335-341. | Series/Report no.: | Nature | Abstract: | THE Bcl-2 family of proteins regulate programmed cell death by an unknown mechanism1. Here we describe the crystal and solution structures of a Bcl-2 family member, Bcl-xL (ref. 2). The structures consist of two central, primarily hydrophobic α-helices, which are surrounded by amphipathic helices. A 60-residue loop connecting helices αl and α2 was found to be flexible and non-essential for anti-apoptotic activity. The three functionally important Bcl-2 homology regions (BH1, BH2 and BH3)3–5 are in close spatial proximity and form an elongated hydrophobic cleft that may represent the binding site for other Bcl-2 family members. The arrangement of the α-helices in Bcl-xL is reminiscent of the membrane translocation domain of bacterial toxins, in particular diphtheria toxin and the colicins6. The structural similarity may provide a clue to the mechanism of action of the Bcl-2 family of proteins. | URI: | https://hdl.handle.net/10356/95496 http://hdl.handle.net/10220/8302 |
DOI: | 10.1038/381335a0 | Schools: | School of Biological Sciences | Rights: | © 1996 Nature Publishing Group. This is the author created version of a work that has been peer reviewed and accepted for publication by Nature, Nature Publishing Group. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI: http://dx.doi.org/10.1038/381335a0 ] | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Journal Articles |
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38. X-ray and NMR structure of Bcl-XL, an inhibitor of programmed cell death (1).pdf | 1.08 MB | Adobe PDF | View/Open |
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