Nanoscale-controlled enzymatic degradation of poly(L-lactic acid) films using dip-pen nanolithography
Boey, Freddy Yin Chiang
Venkatraman, Subbu S.
Date of Issue2011
School of Materials Science and Engineering
Proteinase K is patterned on poly(L-lactic acid) (PLLA) film by agarose-assisted dip-pen nanolithography. Lateral biodegradation at the nanometer scale on PLLA film is faster than vertical biodegradation. The height and diameter of the patterned proteinase K dots can affect the depth of the biodegraded holes, while the concentration of the proteinase K solution (the ink used to coat the AFM tip) does not affect the biodegradation.
© 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.