Chemical analysis of silica doped hydroxyapatite biomaterials consolidated by a spark plasma sintering method
Khor, Khiam Aik
Date of Issue2006
School of Mechanical and Aerospace Engineering
Silica (SiO2) and the silicate-based biomaterials play an important role due to their in vitro and in vivo biological response. The present study synthesized a novel nano-structured amorphous silica doped hydroxyapatite (HA) via an aqueous precipitation route. HA was prepared with 0, 1, 3 and 5 wt% silica, which are comparable to the measured silicon content of natural bone. After spray drying into micron sized powders, the silica doped HA (SiHA) powders were consolidated at 1000 C with a dwell time of 3 min using a spark plasma sintering (SPS) technique. X-ray diffraction analysis showed a main apatite phase with minor secondary b-tricalcium phosphate (b-TCP) was observed in the as-consolidated SiHA compacts. Substitution of PO3- 4 by SiO4- 4 in the apatite structure resulting in a small increase in the lattice parameters in both a-axis and c-axis of the unit cell were identified by X-ray photoelectron spectrometer (XPS) analysis and Raman spectrometer investigation. The cell culture in vitro investigation demonstrated that the presence of silicon in the SPS consolidated compacts contributed to the relatively high cell proliferation ability when compared with phase pure HA.
Journal of inorganic biochemistry
© 2006 Elsevier Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Inorganic Biochemistry, Elsevier Inc.. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: DOI: [http://dx.doi.org/10.1016/j.jinorgbio.2006.09.030].