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CMOS high density electrical impedance biosensor array for tumor cell detection.

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CMOS high density electrical impedance biosensor array for tumor cell detection.

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Title: CMOS high density electrical impedance biosensor array for tumor cell detection.
Author: Chen, Yu.; Wong, Chee Chung.; Pui, Tze Sian.; Nadipalli, Revanth.; Weerasekera, Roshan.; Chandran, Jegatha; Yu, Hao.; Rahman, Abdur Rub Abdur.
Copyright year: 2012
Abstract: We present a high-throughput label-free electrical-impedance spectroscopy (EIS) platform composed of a 96 × 96 microelectrode array for counting and analysis of breast tumor cells (MCF-7). These Auelectrodes are densely packed within a 3.5 mm × 3.5 mm interrogation region. Each Au-electrode has an edge-length of 25 μm designed to detect single tumor cell by electrical impedance spectroscopy. The detected signal is read out via an integrated circuit (IC) of addressable electrode-selection-switch array manufactured with 0.18μm CMOS technology. The independently addressable microelectrode array is integrated onto a printed circuit board (PCB) containing associated circuitry for electrode switching and readout. MCF-7 cells were dispensed onto the chip surface and EIS measurements were recorded before and after the cell dispensation. On an average 20% increase in impedance was found associated with cell occupancy on the electrode surface. A positive correlation was observed between cell detection with optical microscopy and with electrical scanning.
Subject: DRNTU::Engineering::Electrical and electronic engineering.
Type: Journal Article
Series/ Journal Title: Sensors and actuators B : chemical
School: School of Electrical and Electronic Engineering
Rights: © 2012 Elsevier B. V. This is the author created version of a work that has been peer reviewed and accepted for publication by Sensors and actuators B: chemical, Elsevier B. V. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: http://dx.doi.org/10.1016/j.snb.2012.07.024.
Version: Accepted version

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