Aqueous re-dispersibility of spray-dried antibiotic-loaded PLGA nanoparticle aggregates for inhaled anti-biofilm therapy
Date of Issue2011
School of Chemical and Biomedical Engineering
Chronic obstructive pulmonary disease is the fourth leading cause of death globally (Fig. 1). Inhaled antibiotic-loaded nanoparticles (NPs) have emerged as an attractive lung biofilm infection therapy for NPs can penetrate mucus layer surrounding biofilm colonies. NPs made from Poly(lactic-co-glycolic acid) (PLGA), with phosphatidylcholine (PC) as the surfactant (i.e. PLGA-PC) is a biodegradable and biocompatible vehicle for drug delivery. The dry-powder inhaler (DPI) (Fig. 2) is chosen as the delivery platform due to it's high delivery efficiency and stability. To formulate nano-aggregates with aerodynamic characteristics ideal for an effective lung deposition, NP suspension is transformed to DPI by the spray drying technique with different excipients to form aggregates with aerodynamic diameter (dA) between 1 – 5 μm. The nano-aggregates are specifically designed to re-disperse upon inhalation and transportation to the target. [3rd Award]
Student Research Poster
© 2011 The Author(s).