Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/107538
Title: Role of chaperones in selective autophagy of protein inclusions
Authors: Ng, Yan Ting
Keywords: Protein aggregates
Macroautophagy
Issue Date: 2012
Source: Ng, Y. T. (2012, March). Role of chaperones in selective autophagy of protein inclusions. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore.
Abstract: Autophagy is a catabolic process that facilitates degradation of intracellular components in lysosomes[1] (Fig. 1). Up-regulation of autophagy to clear protein inclusions has been shown to alleviate pathogenesis of various neurodegenerative diseases and represents an attractive therapeutic approach to slow down disease progression[1-2]. However, we have found that autophagic clearance of disease-linked inclusions is not a universal phenomenon and, instead, cells target the removal of these protein inclusions in a selective manner[3] (Fig. 1). Currently, the factor(s) governing selection of protein inclusions for autophagic degradation is not well understood. Chaperones and co-chaperones, which modulate protein quality control, have recently been suggested to be critical in this selection process[4]. In this study, we seek to investigate whether the association of pertinent chaperone(s) with protein inclusions determines the susceptibility of protein inclusions toward autophagic degradation. [3rd Award]
URI: https://hdl.handle.net/10356/107538
http://hdl.handle.net/10220/9089
Rights: © 2012 The Author(s).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:URECA Posters

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