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|Title:||Role of chaperones in selective autophagy of protein inclusions||Authors:||Ng, Yan Ting||Keywords:||Protein aggregates
|Issue Date:||2012||Source:||Ng, Y. T. (2012, March). Role of chaperones in selective autophagy of protein inclusions. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore.||Abstract:||Autophagy is a catabolic process that facilitates degradation of intracellular components in lysosomes (Fig. 1). Up-regulation of autophagy to clear protein inclusions has been shown to alleviate pathogenesis of various neurodegenerative diseases and represents an attractive therapeutic approach to slow down disease progression[1-2]. However, we have found that autophagic clearance of disease-linked inclusions is not a universal phenomenon and, instead, cells target the removal of these protein inclusions in a selective manner (Fig. 1). Currently, the factor(s) governing selection of protein inclusions for autophagic degradation is not well understood. Chaperones and co-chaperones, which modulate protein quality control, have recently been suggested to be critical in this selection process. In this study, we seek to investigate whether the association of pertinent chaperone(s) with protein inclusions determines the susceptibility of protein inclusions toward autophagic degradation. [3rd Award]||URI:||https://hdl.handle.net/10356/107538
|Rights:||© 2012 The Author(s).||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||URECA Posters|
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