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Title: Effects of LNA modification on the stability and structure of DNA G-quadruplex
Authors: Li, Zhe
Keywords: DNA
Issue Date: 2011
Source: Li, Z. (2011, March). Effects of LNA modification on the stability and structure of DNA G-quadruplex. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore.
Abstract: Formation of G-quadruplex by DNA can inhibit activity of telomerase, hence stop proliferation of cancer cells[1-2]. Thus, quadruplex-forming oligonucleotides have promising anticancer pharmaceutical potential. Because of LNA’s (Locked Nucleic Acid) biostability[3], the lifetime of LNA modified oligonucleotide can be prolonged. Knowledge of the LNA modified G-quadruplex’s stability and structure[4-5] can help in drug design. This project uses various biophysical techniques including 1D and 2D NMR (Nuclear Magnetic Resonance), CD (Circular Dichroism) and UV (UltraViolet) absorption spectroscopy to investigate the effect of LNA modifications on a quadruplex-forming human telomeric sequence. [2nd Award]
Rights: © 2011 The Author(s).
metadata.item.grantfulltext: open
metadata.item.fulltext: With Fulltext
Appears in Collections:URECA Posters

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