Effect of hydrogen bond interaction on protein phase transition
Leong, Hon Wai
Chew, Lock Yue
Date of Issue2012
School of Physical and Mathematical Sciences
High Performance Computing Centre
We derive the grand partition function of protein chain by restricting dihedral angles to exist only in five distinct states and assume that the dominant noncovalent potential is the hydrogen bond interaction. We investigate the phase transition of protein secondary structures and the order of the transition through analyzing its heat capacity. Our theory demonstrates the presence of α-β-coil structural phase transition in the protein polyalanine.
Physical review E
© 2012 American Physical Society. This paper was published in Physical Review E and is made available as an electronic reprint (preprint) with permission of American Physical Society. The paper can be found at the following official DOI: [http://dx.doi.org/10.1103/PhysRevE.86.031902]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.