Please use this identifier to cite or link to this item:
Title: Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy
Authors: Tan, Tien-En
Nguyen, Quang
Chua, Jacqueline
Schmetterer, Leopold
Tan, Gavin Siew Wei
Wong, Chee Wai
Tsai, Andrew
Cheung, Gemmy Chui Ming
Wong, Tien Yin
Ting, Daniel Shu Wei
Keywords: Science::Medicine
Diabetes Complications
Issue Date: 2019
Source: Tan, T.-E., Nguyen, Q., Chua, J., Schmetterer, L., Tan, G. S. W., Wong, C. W., . . . Ting, D. S. W. (2019). Global assessment of retinal arteriolar, venular and capillary microcirculations using fundus photographs and optical coherence tomography angiography in diabetic retinopathy. Scientific Reports, 9(1), 11751-. doi:10.1038/s41598-019-47770-9
Series/Report no.: Scientific Reports
Abstract: Retinal arterioles, venules and capillaries are differentially affected in diabetes, and studying vascular alterations may provide information on pathogenesis of diabetic retinopathy (DR). We conducted a cross-sectional study on 49 diabetic patients, who underwent fundus photography and optical coherence tomographic angiography (OCT-A). Fundus photographs were analysed using semi-automated software for arteriolar and venular parameters, including central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) and fractal dimension (FD). Capillary parameters were measured using OCT-A, including capillary density index (CDI) and capillary FD of superficial (SVP) and deep (DVP) vascular plexuses. Severe DR was defined as severe non-proliferative DR and proliferative DR. We found that eyes with severe DR had narrower CRAE and sparser SVP CDI than eyes without. In logistic regression analysis, capillary parameters were more associated with severe DR than arteriolar or venular parameters. However, combining arteriolar, venular and capillary parameters provided the strongest association with severe DR. In linear regression analysis, eyes with poorer visual acuity had lower CRAE and FD of arterioles, venules, and DVP capillaries. We concluded that the retinal microvasculature is globally affected in severe DR, reflecting widespread microvascular impairment in perfusion. Arteriolar, venular and capillary parameters provide complementary information in assessment of DR.
DOI: 10.1038/s41598-019-47770-9
Rights: © 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

Files in This Item:
File Description SizeFormat 
Global Assessment of Retinal.pdf1.31 MBAdobe PDFThumbnail

Citations 1

Updated on Aug 31, 2020

Citations 50

Updated on Nov 27, 2020

Page view(s)

Updated on Dec 3, 2020

Download(s) 50

Updated on Dec 3, 2020

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.