Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/100431
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dc.contributor.authorWen, Hanchunen
dc.contributor.authorWang, Keen
dc.contributor.authorLiu, Yangen
dc.contributor.authorTay, Martinen
dc.contributor.authorLauro, Federico M.en
dc.contributor.authorHuang, Hongen
dc.contributor.authorWu, Huayuen
dc.contributor.authorLiang, Hongjieen
dc.contributor.authorDing, Yichenen
dc.contributor.authorGivskov, Michaelen
dc.contributor.authorChen, Yiqiangen
dc.contributor.authorYang, Liangen
dc.date.accessioned2015-06-02T06:19:50Zen
dc.date.accessioned2019-12-06T20:22:28Z-
dc.date.available2015-06-02T06:19:50Zen
dc.date.available2019-12-06T20:22:28Z-
dc.date.copyright2014en
dc.date.issued2014en
dc.identifier.citationWen, H., Wang, K., Liu, Y., Tay, M., Lauro, F. M., Huang, H., et al. (2014). Population dynamics of an acinetobacter baumannii clonal complex during colonization of patients. Journal of clinical microbiology, 52(9), 3200-3208.en
dc.identifier.urihttps://hdl.handle.net/10356/100431-
dc.identifier.urihttp://hdl.handle.net/10220/25736en
dc.description.abstractAcinetobacter baumannii has emerged as one of the leading pathogens causing hospital-acquired infection. The success of A. baumannii as a pathogen has to a large extent been attributed to its capacity to remodel its genome. Several major epidemic clonal complexes of A. baumannii spread across different health care facilities around the world, each of which contains a subset of diversified strains. However, little is known about the population dynamics during colonization of A. baumannii within hosts. Here, whole-genome sequencing was used to analyze population dynamics of A. baumannii strains isolated from a group of patients at different time points as well as from different sites of a particular patient. Seven out of nine of the sampled A. baumannii strains belonged to the international clone II (CC92 clonal complex). While the A. baumannii strains were found to be stable in three patients, there was a change of A. baumannii strains in one patient. Comparative genomic analysis revealed that the accessory genome of these strains contained a large set of virulence-encoding genes and these virulence factors might play a role in determining population dynamics. Microscale genome modification has been revealed by analysis of single nucleotide polymorphisms (SNPs) between A. baumannii strains isolated from the same patient. Parallel evolutionary traits have been observed during genome diversification when A. baumannii colonize in different patients. Our study suggested that both antibiotic usage and host environment might impose selective forces that drive the rapid adaptive evolution in colonizing A. baumannii.en
dc.format.extent9 p.en
dc.language.isoenen
dc.relation.ispartofseriesJournal of clinical microbiologyen
dc.rights© 2014 American Society for Microbiology. This paper was published in Journal of Clinical Microbiology and is made available as an electronic reprint (preprint) with permission of American Society for Microbiology. The paper can be found at the following official DOI: [http://dx.doi.org/10.1128/JCM.00921-14]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en
dc.subjectDRNTU::Science::Biological sciences::Microbiologyen
dc.titlePopulation dynamics of an acinetobacter baumannii clonal complex during colonization of patientsen
dc.typeJournal Articleen
dc.contributor.schoolInterdisciplinary Graduate School (IGS)en
dc.contributor.schoolSchool of Biological Sciencesen
dc.contributor.organizationSingapore Centre for Environmental Life Sciences Engineeringen
dc.identifier.doi10.1128/JCM.00921-14en
dc.description.versionPublished versionen
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