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Title: Electrochemical biosensor based on graphene oxide–Au nanoclusters composites for l-cysteine analysis
Authors: Ge, Shenguang
Yan, Mei
Lu, Juanjuan
Zhang, Meng
Yu, Feng
Yu, Jinghua
Song, Xianrang
Yu, Shilin
Issue Date: 2011
Source: Ge, S., Yan, M., Lu, J., Zhang, M., Yu, F., Yu, Jinghua, et al. (2011). Electrochemical biosensor based on graphene oxide–Au nanoclusters composites for l-cysteine analysis. Biosensors and Bioelectronics, 31, 49-54.
Series/Report no.: Biosensors and bioelectronics
Abstract: In this paper, a linker-free connected graphene oxide/Au nanocluster (GO–Au NCs) composite was prepared under sonication through electrostatic interactions, and characterized by transmission electron microscope (TEM), atomic force microscope (AFM), ultraviolet–visible (UV–vis) and FT-IR spectrum. The morphological and structural characterizations evidence that the Au NCs can be efficiently decorated on the GO. The electrochemical investigations indicated that GO–Au NCs composite has an important role in the electrocatalytic activity towards the oxidation of l-cysteine (CySH). The GO–Au NCs composite modified electrode shows a large determination range from 0.05 to 20.0 μmol/L, a remarkably low detection limit is 0.02 μmol/L and low oxidation potential (+0.387). It was found that metal ions, carbohydrates, nucleotide acids and amino acids had no distinct effect on the determination of l-cysteine. In addition, the sensor has some important advantages such as simple preparation, fast response, good stability and high reproducibility. The direct determination of free reduced and total CySH in human urine samples has been successfully carried out without the assistance of any separation techniques.
ISSN: 0956-5663
DOI: 10.1016/j.bios.2011.09.038
Rights: © 2011 Elsevier B.V.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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