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https://hdl.handle.net/10356/100793
Title: | Structure of human Rack1 protein at a resolution of 2.45 Å | Authors: | Lescar, Julien Cornvik, Tobias Carl Liew, Chong Wai Tan, Suet Mien Ruiz Carrillo, David Chandrasekaran, Ramya Nilsson, Martina |
Keywords: | DRNTU::Science::Biological sciences::Biochemistry DRNTU::Science::Chemistry::Crystallography |
Issue Date: | 2012 | Source: | Ruiz Carrillo, D., Chandrasekaran, R., Nilsson, M., Cornvik, T. C., Liew, C. W., Tan, S. M., et al. (2012). Structure of human Rack1 protein at a resolution of 2.45 Å. Acta crystallographica section F structural biology and crystallization communications, 68(8), 867-872. | Series/Report no.: | Acta crystallographica section F structural biology and crystallization communications | Abstract: | The crystal structure of human receptor for activated C-kinase 1 (hRack1) protein is reported at 2.45 Å resolution. The crystals belongs to space group P41212, with three molecules per asymmetric unit. The hRack1 structure features a sevenfold -propeller, with each blade housing a sequence motif that contains a strictly conserved Trp, the indole group of which is embedded between adjacent blades. In blades 1-5 the imidazole group of a His residue is wedged between the side chains of a Ser residue and an Asp residue through two hydrogen bonds. The hRack1 crystal structure forms a starting basis for understanding the remarkable scaffolding properties of this protein. | URI: | https://hdl.handle.net/10356/100793 http://hdl.handle.net/10220/9300 |
ISSN: | 1744-3091 | DOI: | 10.1107/S1744309112027480 | Rights: | © 2012 International Union of Crystallography. This paper was published in Acta Crystallographica Section F Structural Biology and Crystallization Communications and is made available as an electronic reprint (preprint) with permission of International Union of Crystallography. The paper can be found at the following official DOI: [http://dx.doi.org/10.1107/S1744309112027480]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Journal Articles |
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3. Structure of human Rack1 protein at a resolution of 2.45 Å.pdf | 1.22 MB | Adobe PDF | ![]() View/Open |
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