Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/100865
Title: 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes
Authors: Lech, Christopher Jacques
Li, Zhe
Heddi, Brahim
Phan, Anh Tuân
Issue Date: 2012
Source: Lech, C. J., Li, Z., Heddi, B., & Phan, A. T. (2012). 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes. Chemical Communications, 48, 11425-11427.
Series/Report no.: Chemical communications
Abstract: Here we demonstrate the applicability of 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for manipulating G-quadruplex folding by anti-position-favoring substitutions. A single guanine to 2′-F-ANA-guanine substitution can favor a single (3+1) hybrid conformation from a mixture of conformers. Rational substitutions of either type of 2′-F-modified nucleotide enable conformational switching from a (3+1) hybrid to a parallel folding topology.
URI: https://hdl.handle.net/10356/100865
http://hdl.handle.net/10220/11049
DOI: 10.1039/c2cc35097a
Rights: © 2012 The Royal Society of Chemistry.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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