Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/100865
Title: | 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes | Authors: | Lech, Christopher Jacques Li, Zhe Heddi, Brahim Phan, Anh Tuân |
Issue Date: | 2012 | Source: | Lech, C. J., Li, Z., Heddi, B., & Phan, A. T. (2012). 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes. Chemical Communications, 48, 11425-11427. | Series/Report no.: | Chemical communications | Abstract: | Here we demonstrate the applicability of 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for manipulating G-quadruplex folding by anti-position-favoring substitutions. A single guanine to 2′-F-ANA-guanine substitution can favor a single (3+1) hybrid conformation from a mixture of conformers. Rational substitutions of either type of 2′-F-modified nucleotide enable conformational switching from a (3+1) hybrid to a parallel folding topology. | URI: | https://hdl.handle.net/10356/100865 http://hdl.handle.net/10220/11049 |
DOI: | 10.1039/c2cc35097a | Rights: | © 2012 The Royal Society of Chemistry. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | SPMS Journal Articles |
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