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Title: Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Authors: Eickhardt-Sørensen, Steffen R.
Sørensen, Søren J.
Kerpedjiev, Peter
Jakobsen, Tim Holm
Hansen, Martin Asser
Jensen, Peter Østrup
Hansen, Lars
Riber, Leise
Cockburn, April
Kolpen, Mette
Rønne Hansen, Christine
Ridderberg, Winnie
Hansen, Marlene
Alhede, Morten
Qvortrup, Klaus
Burmølle, Mette
Moser, Claus
Kühl, Michael
Ciofu, Oana
Givskov, Michael
Høiby, Niels
Bjarnsholt, Thomas
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2013
Source: Jakobsen, T. H., Hansen, M. A., Jensen, P. Ø., Hansen, L., Riber, L., Cockburn, A., et al. (2013). Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes. PLoS ONE, 8(7), e68484-.
Series/Report no.: PLoS ONE
Abstract: Achromobacter xylosoxidans is an environmental opportunistic pathogen, which infects an increasing number of immunocompromised patients. In this study we combined genomic analysis of a clinical isolated A. xylosoxidans strain with phenotypic investigations of its important pathogenic features. We present a complete assembly of the genome of A. xylosoxidans NH44784-1996, an isolate from a cystic fibrosis patient obtained in 1996. The genome of A. xylosoxidans NH44784-1996 contains approximately 7 million base pairs with 6390 potential protein-coding sequences. We identified several features that render it an opportunistic human pathogen, We found genes involved in anaerobic growth and the pgaABCD operon encoding the biofilm adhesin poly-β-1,6-N-acetyl-D-glucosamin. Furthermore, the genome contains a range of antibiotic resistance genes coding efflux pump systems and antibiotic modifying enzymes. In vitro studies of A. xylosoxidans NH44784-1996 confirmed the genomic evidence for its ability to form biofilms, anaerobic growth via denitrification, and resistance to a broad range of antibiotics. Our investigation enables further studies of the functionality of important identified genes contributing to the pathogenicity of A. xylosoxidans and thereby improves our understanding and ability to treat this emerging pathogen.
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0068484
Rights: © 2013 The Author(s). This paper was published in PLoS ONE and is made available as an electronic reprint (preprint) with permission of The Author(s). The paper can be found at the following official DOI:  One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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