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|Title:||An epigenetic profile of early T-cell development from multipotent progenitors to committed T-cell descendants||Authors:||Vigano, Maria Alessandra
van Nimwegen, Erik
|Keywords:||DRNTU::Science::Medicine||Issue Date:||2013||Source:||Vigano, M. A., Ivanek, R., Balwierz, P., Berninger, P., van Nimwegen, E., Karjalainen, K., & et al. (2014). An epigenetic profile of early T-cell development from multipotent progenitors to committed T-cell descendants. European Journal of Immunology, 44(4), 1181-1193.||Series/Report no.:||European journal of immunology||Abstract:||Cellular differentiation of the T-cell branch of the immune system begins with the HSC, which undergoes a series of stages characterized by progressive restriction in multipotency and acquisition of specific lineage identity At the molecular level, the restriction of cell potential, commitment, and differentiation to a specific lineage is achieved through the coordinated control of gene expression and epigenetic mechanisms. Here, we analyzed and compared the gene expression profiles and the genome-wide histone modification marks H3K4me3 (H3 lysine 4 trimethylation) and H3K27me3 (H3 lysine 27 trimethylation) in (i) in vitro propagated HSCs, (ii) in vitro generated and propagated pro-T cells derived from these stem cells, and (iii) double-positive thymocytes derived from these pro-T cells after injection into Rag-deficient mice. The combined analyses of the different datasets in this unique experimental system highlighted the importance of both transcriptional and epigenetic repression in shaping the early phases of T-cell development.||URI:||https://hdl.handle.net/10356/101205
|ISSN:||0014-2980||DOI:||10.1002/eji.201344022||Rights:||© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SBS Journal Articles|
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