Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/101252
Title: Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo
Authors: Rice, Scott A.
Kumar, Naresh
Ho, Kitty Ka Kit
Cole, Nerida
Chen, Renxun
Willcox, Mark D. P.
Issue Date: 2012
Source: Ho, K. K. K., Cole, N., Chen, R., Willcox, M. D. P., Rice, S. A., & Kumar, N. (2012). Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo. Antimicrobial Agents and Chemotherapy, 56(2), 1138-1141.
Series/Report no.: Antimicrobial agents and chemotherapy
Abstract: Antibiotic-resistant Staphylococcus aureus is of great concern, as it causes a wide range of life-threatening infections. The current study demonstrates that dihydropyrrolone (DHP)-coated polyacrylamide substrates are effective in reducing the number of culturable clinical isolates of S. aureus in vitro in a dose-dependent manner and are able to reduce the pathogenic potential of staphylococcal infection in a subcutaneous infection model. Covalently bound DHPs therefore show great potential for use as an antimicrobial strategy in device-related applications.
URI: https://hdl.handle.net/10356/101252
http://hdl.handle.net/10220/10995
ISSN: 0066-4804
DOI: 10.1128/AAC.05814-11
Rights: © 2012 American Society for Microbiology.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCELSE Journal Articles

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