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|Title:||Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo||Authors:||Rice, Scott A.
Ho, Kitty Ka Kit
Willcox, Mark D. P.
|Issue Date:||2012||Source:||Ho, K. K. K., Cole, N., Chen, R., Willcox, M. D. P., Rice, S. A., & Kumar, N. (2012). Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo. Antimicrobial Agents and Chemotherapy, 56(2), 1138-1141.||Series/Report no.:||Antimicrobial agents and chemotherapy||Abstract:||Antibiotic-resistant Staphylococcus aureus is of great concern, as it causes a wide range of life-threatening infections. The current study demonstrates that dihydropyrrolone (DHP)-coated polyacrylamide substrates are effective in reducing the number of culturable clinical isolates of S. aureus in vitro in a dose-dependent manner and are able to reduce the pathogenic potential of staphylococcal infection in a subcutaneous infection model. Covalently bound DHPs therefore show great potential for use as an antimicrobial strategy in device-related applications.||URI:||https://hdl.handle.net/10356/101252
|ISSN:||0066-4804||DOI:||10.1128/AAC.05814-11||Rights:||© 2012 American Society for Microbiology.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SCELSE Journal Articles|
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