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dc.contributor.authorSuchitra, Natarajanen_US
dc.contributor.authorSabine, Hombach-Klonischen_US
dc.contributor.authorPeter, Drögeen_US
dc.contributor.authorThomas, Klonischen_US
dc.identifier.citationSuchitra, N., Sabine, H.-K., Peter, D., & Thomas, K. (2013). HMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells. Neoplasia, 15(3), 263-280.en_US
dc.description.abstractThe non-histone chromatin binding protein high mobility group AT-hook 2 (HMGA2) is expressed in stem cells and many cancer cells, including tumor initiating cells, but not translated in normal human somatic cells. The presence of HMGA2 is correlated with advanced neoplastic disease and poor prognosis for patients. We had previously demonstrated a role of HMGA2 in DNA repair pathways. In the present study, we employed different human tumor cell models with endogenous and exogenous expression of HMGA2 and show that upon DNA damage, the presence of HMGA2 caused an increased and sustained phosphorylation of the ataxia telangiectasia and Rad3-related kinase (ATR) and its downstream target checkpoint kinase 1 (CHK1). The presence of activated pCHK1Ser296 coincided with prolonged G2/M block and increased tumor cell survival, which was enhanced further in the presence of HMGA2. Our study, thus, identifies a novel relationship between the ATR-CHK1 DNA damage response pathway and HMGA2, which may support the DNA repair function of HMGA2 in cancer cells. Furthermore, our data provide a rationale for the use of inhibitors to ATR or CHK1 and HMGA2 in the treatment of HMGA2-positive human cancer cells.en_US
dc.rights© 2013 Neoplasia Press, Inc.en_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleHMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cellsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
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