Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/101633
Title: Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells
Authors: Cousins, Brian G.
Hamblin, Michael R.
Alavijeh, Mohammad S.
Seifalian, Alexander M.
Malkovskiy, Andrey V.
Rajadas, Jayakumar
Tan, Aaron
Farhatnia, Yasmin
Goh, Debbie
G, Natasha
de Mel, Achala
Lim, Jing
Teoh, Swee-Hin
Chawla, Reema
Keywords: DRNTU::Engineering::Chemical engineering::Biochemical engineering
Issue Date: 2013
Source: Tan, A., Farhatnia, Y., Goh, D., G, N., de Mel, A., Lim, J., et al. (2013). Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells. Biointerphases, 8(1), 23-40.
Series/Report no.: Biointerphases
Abstract: An unmet need exists for the development of next-generation multifunctional nanocomposite materials for biomedical applications, particularly in the field of cardiovascular regenerative biology. Herein, we describe the preparation and characterization of a novel polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer with covalently attached anti-CD34 antibodies to enhance capture of circulating endothelial progenitor cells (EPC). This material may be used as a new coating for bare metal stents used after balloon angioplasty to improve re-endothelialization. Biophysical characterization techniques were used to assess POSS-PCU and its subsequent functionalization with anti-CD34 antibodies. Results indicated successful covalent attachment of anti-CD34 antibodies on the surface of POSS-PCU leading to an increased propensity for EPC capture, whilst maintaining in vitro biocompatibility and hemocompatibility. POSS-PCU has already been used in 3 first-in-man studies, as a bypass graft, lacrimal duct and a bioartificial trachea. We therefore postulate that its superior biocompatibility and unique biophysical properties would render it an ideal candidate for coating medical devices, with stents as a prime example. Taken together, anti-CD34 functionalized POSS-PCU could form the basis of a nano-inspired polymer platform for the next generation stent coatings.
URI: https://hdl.handle.net/10356/101633
http://hdl.handle.net/10220/18652
ISSN: 1559-4106
DOI: 10.1186/1559-4106-8-23
Rights: © 2013 The Author(s). This paper was published in Biointerphases and is made available as an electronic reprint (preprint) with permission of The Author(s). The paper can be found at the following official DOI: [http://dx.doi.org/10.1186/1559-4106-8-23]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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