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dc.contributor.authorLi, Huaqiongen
dc.contributor.authorWong, Yee Shanen
dc.contributor.authorWen, Fengen
dc.contributor.authorNg, Kee Woeien
dc.contributor.authorNg, Gary Ka Laien
dc.contributor.authorVenkatraman, Subbu S.en
dc.contributor.authorBoey, Freddy Yin Chiangen
dc.contributor.authorTan, Lay Pohen
dc.identifier.citationLi, H., Wong, Y. S., Wen, F., Ng, K. W., Ng, G. K. L., Venkatraman, S. S., et al. (2013). Human Mesenchymal Stem-Cell Behaviour On Direct Laser Micropatterned Electrospun Scaffolds with Hierarchical Structures. Macromolecular Bioscience, 13(3), 299-310.en
dc.description.abstractDirect laser machining and electrospinning are utilized to obtain a bi-layered hybrid scaffold with hierarchical topographical features to mimic extracellular matrix-like microenvironment of cells. Adult bone marrow derived human mesenchymal stem cells (hMSCs) are cultured in vitro in these hybrid scaffolds, and cell orientation, proliferation, viability, and differentiation are evaluated. The results show that this novel hybrid scaffold not only supports cell growth like traditional scaffolds, but also elicits positive responses from the cells, like lineage commitment and alignment, which are essential features of future scaffolds.en
dc.relation.ispartofseriesMacromolecular bioscienceen
dc.rights© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en
dc.subjectDRNTU::Science::Biological sciences::Molecular biologyen
dc.titleHuman mesenchymal stem-cell behaviour on direct laser micropatterned electrospun scaffolds with hierarchical structuresen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.contributor.organizationA*STAR SIMTechen
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SIMTech Journal Articles

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