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Title: Distance-mediated plasmonic dimers for reusable colorimetric switches : a measurable peak shift of more than 60 nm
Authors: Li, Chang Ming
Guo, Longhua
Ferhan, Abdul Rahim
Chen, Hailan
Chen, Guonan
Hong, Seungpyo
Kim, Dong-Hwan
Keywords: DRNTU::Engineering::Chemical engineering
Issue Date: 2013
Source: Guo, L., Ferhan, A. R., Chen, H., Li, C. M., Chen, G., Hong, S., et al. (2013). Distance-mediated plasmonic dimers for reusable colorimetric switches : a measurable peak shift of more than 60 nm. Small, 9(2), 234-240.
Series/Report no.: Small
Abstract: The first reconfigurable colorimetric DNA switches based on target DNA binding are reported. This DNA binding actuates a change in the interparticle distance between gold nanoparticle dimers. A significant spectral shift of 68 nm is achievable from on-off switching. The reconfigurability is possible owing to thiol and EDC-imidazole coupling which anchors the DNA linkers to the nanoparticles. The huge spectral shift allows the unaided eye to observe single target biomolecular binding event in real time under a darkfield microscope. The limit-of-detection for target molecules in PBS and human serum are 10−13 M and 10−11 M respectively. An improved fabrication strategy via asymmetric functionalization is also described, assisted by solid phase synthesis which minimizes the formation of trimers and multimers.
ISSN: 1613-6810
DOI: 10.1002/smll.201201061
Rights: © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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