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Title: Discovery of a structural-element specific G-quadruplex “light-up” probe
Authors: Zhao, Wei
Phan, Anh Tuân
Chang, Young-Tae
Yoo, Jaeduk
Xu, Wang
Zhang, Liyun
Er, Jun Cheng
Ghosh, Krishna Kanta
Chung, Wan Jun
Keywords: DRNTU::Science::Mathematics
Issue Date: 2014
Source: Zhang, L., Er, J. C., Ghosh, K. K., Chung, W. J., Yoo, J., Xu, W., et al. (2014). Discovery of a Structural-Element Specific G-Quadruplex “Light-Up” Probe. Scientific Reports, 4, 3776-.
Series/Report no.: Scientific reports
Abstract: The development of a fluorescent probe capable of detecting and distinguishing the wide diversity of G-quadruplex structures is particularly challenging. Herein, we report a novel BODIPY-based fluorescent sensor (GQR) that shows unprecedented selectivity to parallel-stranded G-quadruplexes with exposed ends and four medium grooves. Mechanistic studies suggest that GQR associates with G-quadruplex grooves close to the end of the tetrad core, which may explain the dye's specificity to only a subset of parallel structures. This specific recognition favours the disaggregation of GQR in aqueous solutions thereby recovering the inherent fluorescence of the dye. Due to its unique features, GQR represents a valuable tool for basic biological research and the rapid discovery of novel, specific ligands that target similar structural features of G-quadruplexes.
ISSN: 2045-2322
DOI: 10.1038/srep03776
Rights: © 2014 Nature Publishing Group. This paper was published in Scientific Reports and is made available as an electronic reprint (preprint) with permission of Nature Publishing Group. The paper can be found at the following official DOI: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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