Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/102261
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dc.contributor.authorYang, Yueen
dc.contributor.authorCheow, Wean Sinen
dc.contributor.authorHadinoto, Kunnen
dc.date.accessioned2013-10-24T09:01:46Zen
dc.date.accessioned2019-12-06T20:52:21Z-
dc.date.available2013-10-24T09:01:46Zen
dc.date.available2019-12-06T20:52:21Z-
dc.date.copyright2012en
dc.date.issued2012en
dc.identifier.citationYang, Y., Cheow, W. S., & Hadinoto, K. (2012). Dry powder inhaler formulation of lipid–polymer hybrid nanoparticles via electrostatically-driven nanoparticle assembly onto microscale carrier particles. International journal of pharmaceutics, 434(1-2), 49-58.en
dc.identifier.issn0378-5173en
dc.identifier.urihttps://hdl.handle.net/10356/102261-
dc.identifier.urihttp://hdl.handle.net/10220/16847en
dc.description.abstractLipid–polymer hybrid nanoparticles have emerged as promising nanoscale carriers of therapeutics as they combine the attractive characteristics of liposomes and polymers. Herein we develop dry powder inhaler (DPI) formulation of hybrid nanoparticles composed of poly(lactic-co-glycolic acid) and soybean lecithin as the polymer and lipid constituents, respectively. The hybrid nanoparticles are transformed into inhalable microscale nanocomposite structures by a novel technique based on electrostatically-driven adsorption of nanoparticles onto polysaccharide carrier particles, which eliminates the drawbacks of conventional techniques based on controlled drying (e.g. nanoparticle-specific formulation, low yield). First, we engineer polysaccharide carrier particles made up of chitosan cross-linked with tripolyphosphate and dextran sulphate to exhibit the desired aerosolization characteristics and physical robustness. Second, we investigate the effects of nanoparticle to carrier mass ratio and salt inclusion on the adsorption efficiency, in terms of the nanoparticle loading and yield, from which the optimal formulation is determined. Desorption of the nanoparticles from the carrier particles in phosphate buffer saline is also examined. Lastly, we characterize aerosolization efficiency of the nanocomposite product in vitro, where the emitted dose and respirable fraction are found to be comparable to the values of conventional DPI formulations.en
dc.language.isoenen
dc.relation.ispartofseriesInternational journal of pharmaceuticsen
dc.subjectDRNTU::Engineering::Chemical engineeringen
dc.titleDry powder inhaler formulation of lipid–polymer hybrid nanoparticles via electrostatically-driven nanoparticle assembly onto microscale carrier particlesen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijpharm.2012.05.036en
item.grantfulltextnone-
item.fulltextNo Fulltext-
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