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https://hdl.handle.net/10356/102365| Title: | In vitro expressed GPCR inserted in polymersome membranes for ligand-binding studies | Authors: | Low, Ying Xiu De Hoog, Hans-Peter M. May, Sylvia Andreasson-Ochsner, Mirjam Fu, Zhikang Tan, Darren Ritz, Sandra Nallani, Madhavan Sinner, Eva-Kathrin |
Keywords: | DRNTU::Engineering::Materials::Biomaterials | Issue Date: | 2013 | Source: | May, S., Andreasson-Ochsner, M., Fu, Z., Low , Y. X., Tan, D., de Hoog, H.-P. M., et al. (2013). In vitro expressed GPCR inserted in polymersome membranes for ligand-binding studies. Angewandte Chemie International Edition, 52(2), 749-753. | Series/Report no.: | Angewandte chemie international edition | Abstract: | The dopamine receptor D2 (DRD2), a G-protein coupled receptor is expressed into PBd22-PEO13 and PMOXA20-PDMS54-PMOXA20 block copolymer vesicles (see scheme). The conformational integrity of the receptor is confirmed by antibody- and ligand-binding assays. Replacement of bound dopamine is demonstrated on surface-immobilized polymersomes, thus making this a promising platform for drug screening. | URI: | https://hdl.handle.net/10356/102365 http://hdl.handle.net/10220/19016 |
ISSN: | 1433-7851 | DOI: | 10.1002/anie.201204645 | Schools: | School of Materials Science & Engineering | Rights: | © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
| Appears in Collections: | MSE Journal Articles |
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