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Title: Evaluating the toxicity of hydroxyapatite nanoparticles in catfish cells and zebrafish embryos
Authors: Zhao, Xinxin
Ong, Kimberly J.
Ede, James D.
Stafford, James L.
Ng, Kee Woei
Goss, Greg G.
Loo, Joachim Say Chye
Keywords: DRNTU::Engineering::Materials
Issue Date: 2013
Source: Zhao, X., Ong, K. J., Ede, J. D., Stafford, J. L., Ng, K. W., Goss, G. G., et al. (2013). Evaluating the Toxicity of Hydroxyapatite Nanoparticles in Catfish Cells and Zebrafish Embryos. Small, 9(9-10), 1734-1741.
Series/Report no.: Small
Abstract: The toxicity of needle-(nHA-ND) and rod-shaped (nHA-RD) hydroxyapatite (HA) nanoparticles is evaluated in vitro on catfish B-cells (3B11) and catfish T-cells (28s.3) and in vivo on zebrafish embryos to determine if biological effects are similar to the effects seen in mammalian in vitro systems. Neither nHA-ND nor nHA-RD affect cell viability at concentrations of 10 to 300 μg mL−1. However, 30 μg mL−1 needle-shaped nHA lower metabolic activity of the cells. Axial deformations are seen in zebrafish exposed to 300 μg mL−1 needle shaped nHA after 120 h. For the first time, nHA is reported to cause zebrafish hatching delay. The lowest concentration (3 μg mL−1) of both types of nHA cause the highest hatching inhibition and needle-shaped nHA exposed zebrafish exhibit the lowest hatch at 72 h post fertilization.
ISSN: 1613-6810
DOI: 10.1002/smll.201200639
Rights: © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MSE Journal Articles

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