Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/102747
Title: Study of bone morphogenetic protein-2 delivery with different TiO2 nanotube structures
Authors: Tay, Beng Kang
Liang, Kun
Li, Xiao Cheng
Keywords: DRNTU::Engineering::Materials::Nanostructured materials
Issue Date: 2013
Source: Liang, K., Li, X. C., & Tay, B. K. (2013). Study of bone morphogenetic protein-2 delivery with different TiO2 nanotube structures. Nanoscience and Nanotechnology Letters, 5(2), 162-166.
Series/Report no.: Nanoscience and nanotechnology letters
Abstract: A release controlled and localized carrier is important for bone morphogenetic protein delivery in order to enhance the effectiveness in bone repair. In this work, various TiO2 nanotubes with tunable morphologies are fabricated by electrochemical anodization in different organic electrolytes. Their effect on delivery of bone morphogenetic protein-2 (BMP-2) was investigated. During the protein delivery test, it was found that the nanotube structures show superhydrophilic property and tight interaction with protein, compared with the Ti flat surface. The elution profiles of TiO2 nanotube structures have shown slowed down release rate, suppressed initial burst and reduced total amount of BMP-2. The protein retention amount is over 90% for all nanotube structures. The release rate and protein retention are highly related to surface wettability: the more hydrophilic the surface, the slower the release rate and the higher the protein retention. Furthermore, a larger initial burst could be caused by a smaller nanotube density in protein release process.
URI: https://hdl.handle.net/10356/102747
http://hdl.handle.net/10220/19121
ISSN: 1941-4900
DOI: 10.1166/nnl.2013.1492
Rights: © 2013 American Scientific Publishers.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:EEE Journal Articles

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