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Title: Subcutaneous tissue response to titanium, poly(ϵ-caprolactone), and carbonate-substituted hydroxyapatite-coated poly(ϵ-caprolactone) plates : a rabbit study
Authors: Chanchareonsook, Nattharee
Tideman, Henk
Feinberg, Stephen E.
Hollister, Scott J.
Jongpaiboonkit, Leenaporn
Kin, Liao
Jansen, John A.
Keywords: DRNTU::Engineering::Chemical engineering
Issue Date: 2013
Source: Chanchareonsook, N., Tideman, H., Feinberg, S. E., Hollister, S. J., Jongpaiboonkit, L., Kin, L., et al. (2013). Subcutaneous tissue response to titanium, poly(ϵ-caprolactone), and carbonate-substituted hydroxyapatite-coated poly(ϵ-caprolactone) plates: A rabbit study. Journal of Biomedical Materials Research Part A, 101A(8), 2258-2266.
Series/Report no.: Journal of biomedical materials research part A
Abstract: The aim of this study was to evaluate the soft tissue response to poly(ϵ-caprolactone) (PCL) implants with and without carbonate-substituted hydroxyapatite (CHA) coating compared to the commonly used titanium alloy (Ti-6Al-4V)-machined surface. Experimental materials were implanted subcutaneously in New Zealand white rabbits for 5 weeks. The tissue attachment strength, as evaluated by a tissue peel test, histological and histomorphology analysis, as well as scanning electron microscopy were compared between groups. The peel test result revealed no statistically significant difference between groups. Histological analysis found fibrous capsule formation around all implant materials. The fibrous capsule around PCL implants with and without CHA coating was significantly thinner compared with the capsule thickness around the titanium implants. However, the inflammatory cells, as present at the fibrous capsule-implant interface, were found to be significantly lower in the Ti-group. In conclusion, the current data do not prove that PCL or PCL with a CHA coating results in a superior soft tissue response compared with a machined titanium implant.
ISSN: 1549-3296
DOI: 10.1002/jbm.a.34542
Rights: © 2013 Wiley Periodicals, Inc.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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